製品の概要

製品の特性

  • 保存方法
    Store at -20°C. Please refer to protocols.
  • 内容 ラベル 200 µl
    ß -Secretase Substrate (in DMSO)
  • 研究分野
  • 関連性
    Beta secretase is a protease responsible for the proteolytic processing of the amyloid precursor protein (APP). Amyloid beta peptide is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimers disease. This peptide is generated from the beta-amyloid precursor protein (beta APP) in a two-step process. The first step involves cleavage of the extracellular, amino-terminal domain of beta APP. Protein cleavage is performed by an aspartyl protease termed beta-secretase (BACE), of which there are two isoforms, BACE1 and 2. Beta APP cleavage by beta-secretase results in the cellular secretion of a segment of beta APP and a membrane-bound remnant. This remnant is then processed by another protease termed gamma-secretase. Gamma-secretase cleaves an intra-membrane site in the carboxyl-terminal domain of beta APP, thus generating the amyloid beta peptide.
  • 細胞内局在
    Membrane; Single-pass type I membrane protein.
  • 別名
    • APP beta secretase
    • ASP 2
    • ASP2
    • BACE
    • BACE1
    • Beta secretase 1
    • Beta site APP cleaving enzyme 1
    • Memapsin2
    see all

参考文献

ab101160 has not yet been referenced specifically in any publications.

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