Beta Secretase Substrate (ab101160)
製品の概要
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製品名
Beta Secretase Substrate
Beta secretase キット 製品一覧 -
製品の概要
This is a component of Beta Secretase Activity Assay (Fluorometric) (ab65357).
製品の特性
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保存方法
Store at -20°C. Please refer to protocols. -
内容 200 µl β -Secretase Substrate (in DMSO) 1 x 200µl -
研究分野
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関連性
Beta secretase is a protease responsible for the proteolytic processing of the amyloid precursor protein (APP). Amyloid beta peptide is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimers disease. This peptide is generated from the beta-amyloid precursor protein (beta APP) in a two-step process. The first step involves cleavage of the extracellular, amino-terminal domain of beta APP. Protein cleavage is performed by an aspartyl protease termed beta-secretase (BACE), of which there are two isoforms, BACE1 and 2. Beta APP cleavage by beta-secretase results in the cellular secretion of a segment of beta APP and a membrane-bound remnant. This remnant is then processed by another protease termed gamma-secretase. Gamma-secretase cleaves an intra-membrane site in the carboxyl-terminal domain of beta APP, thus generating the amyloid beta peptide. -
細胞内局在
Membrane; Single-pass type I membrane protein. -
別名
- APP beta secretase
- ASP 2
- ASP2
see all
関連製品
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Corresponding kit
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab101160 は論文での使用が確認できていません。