Anti-beta Dystroglycan 抗体 (ab103905)

製品の概要

  • 製品名Anti-beta Dystroglycan antibody
    beta Dystroglycan 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to beta Dystroglycan
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Rat, Human
    交差が予測される動物種: Rabbit, Cow, Dog
  • 免疫原

    Synthetic peptide:

    C-HVGKHEYFMHATDK

    , corresponding to internal sequence amino acids 569-582 of Human beta Dystroglycan (NP_004384.3).

  • ポジティブ・コントロール
    • Human Skeletal Muscle lysates.
  • 特記事項Reported variants represent identical protein: NP_001159400.1, NP_004384.3.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーPreservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)ab103905 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab103905 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 97 kDa.

ターゲット情報

  • 関連性Dystroglycans are essential elements of the neuromuscular junction (NMJ). The gene for dystroglycan is expressed as a precursor protein that is post translationally cleaved into a 156 kDa extracellular peripheral membrane protein called alpha dystroglycan and a 43 kDa transmembrane protein, beta dystroglycan. The latter protein contains a PPxY motif that promotes binding to WW domain containing proteins, such as utrophin and dystrophin. Phosphorylation at tyrosine 892 within the PPxY motif may regulate c Src interactions with beta dystroglycan, as well as inhibit interactions with WW domain proteins. In skeletal muscle, beta dystroglycan is normally localized to the plasma membrane, however phosphorylation of Tyr892 leads to localization of beta dystroglycan to endosomal compartments along with c Src. Thus, phosphorylation at Tyr892 may have important roles in altering the localization of beta dystroglycan during NMJ formation.
  • 細胞内局在Type I membrane protein.
  • 参照データベース
  • 別名
    • 156DAG antibody
    • A3a antibody
    • AGRNR antibody
    • Beta DG antibody
    • Beta dystroglycan antibody
    • DAG 1 antibody
    • DAG1 antibody
    • Dystroglycan antibody
    • Dystrophin associated glycoprotein 1 antibody
    see all

Anti-beta Dystroglycan antibody 画像

  • Anti-beta Dystroglycan antibody (ab103905) at 0.2 µg/ml + Human Skeletal Muscle lysate at 35 µg

    Predicted band size : 97 kDa
  • All lanes : Anti-beta Dystroglycan antibody (ab103905) at 0.1 µg/ml

    Lane 1 : Mouse Skeletal Muscule Lysate in RIPA buffer
    Lane 2 : Rat Skeletal Muscule Lysate in RIPA buffer

    Lysates/proteins at 35 µg per lane.

    Developed using the ECL technique

    Predicted band size : 97 kDa

Anti-beta Dystroglycan antibody (ab103905) 使用論文

ab103905 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"