Anti-beta 2 Microglobulin 抗体 [B2M-01] (Phycoerythrin) (ab49424)

製品の概要

  • 製品名Anti-beta 2 Microglobulin antibody [B2M-01] (Phycoerythrin)
    beta 2 Microglobulin 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [B2M-01] to beta 2 Microglobulin (Phycoerythrin)
  • 標識Phycoerythrin. Ex: 488nm, Em: 575nm
  • 特異性This antibody reacts with beta 2 microglobulin (b2M) associated with cell-surface MHC Class I molecules and other membrane antigens as well as with soluble beta 2 microglobulin. Beta 2 mircoglobulin is a 12 kDa Ig like glycoprotein expressed on lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells and epithelial cells. It is absent on erythrocytes.
  • アプリケーション適用あり: Flow Cytmore details
  • 種交差性
    交差種: Human
    非交差種: Mouse, Rabbit, Chicken, Cow, Dog
  • 免疫原

    Full length native protein (purified) (Human)

  • ポジティブ・コントロール
    • Peripheral blood lymphocytes.
  • 特記事項

    The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab49424 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt Use a concentration of 5 µg/ml.

ターゲット情報

  • 機能Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
  • 関連疾患Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.
    Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.
  • 配列類似性Belongs to the beta-2-microglobulin family.
    Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
  • 翻訳後修飾Glycation of Ile-21 is observed in long-term hemodialysis patients.
  • 細胞内局在Secreted. Detected in serum and urine.
  • Information by UniProt
  • 参照データベース
  • 別名
    • B2M antibody
    • B2MG_HUMAN antibody
    • Beta 2 microglobin antibody
    • Beta 2 microglobulin antibody
    • Beta 2 microglobulin precursor antibody
    • Beta chain of mhc class 1 proteins antibody
    • Beta chain of MHC class I molecules antibody
    • Beta-2-microglobulin form pI 5.3 antibody
    • CDABP0092 antibody
    • Hdcma22p antibody
    see all

Anti-beta 2 Microglobulin antibody [B2M-01] (Phycoerythrin) (ab49424) 使用論文

This product has been referenced in:
  • Khurana M  et al. Urine proteomic profiling of pediatric nephrotic syndrome. Pediatr Nephrol 21:1257-65 (2006). Read more (PubMed: 16810512) »
  • Hilgert I  et al. The use of murine monoclonal antibody B2M-01 for detection and purification of human beta 2-microglobulin. Folia Biol (Praha) 30:369-76 (1984). Read more (PubMed: 6394369) »

See all 2 Publications for this product

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Vielen Dank für die Anfrage. Dass ab46793 nicht auf der Liste auftaucht, bedeutet dass er nicht getestet wurde, ob er mit Maus kreuzreagiert. In der Tat ist ab46793 für die Immunhistochemie (IHC-P/Fr - neben anderen Anwendungen wie Durchflusszy...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"