Anti-beta 2 Adrenergic Receptor 抗体 (ab69598)


  • 製品名Anti-beta 2 Adrenergic Receptor antibody
    beta 2 Adrenergic Receptor 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to beta 2 Adrenergic Receptor
  • 特異性Detects endogenous levels of total beta 2 Adrenergic Receptor protein.
  • アプリケーション適用あり: WB, ELISA, ICC/IFmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic peptide corresponding to Human beta 2 Adrenergic Receptor (internal sequence).

  • ポジティブ・コントロール
    • NIH/3T3 cells, extracts from HeLa cells.



Our Abpromise guarantee covers the use of ab69598 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Detects a band of approximately 60 kDa (predicted molecular weight: 47 kDa).
ELISA 1/20000.
ICC/IF 1/500 - 1/1000.


  • 機能Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
  • 配列類似性Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.
  • 翻訳後修飾Palmitoylated; may reduce accessibility of Ser-345 and Ser-346 by anchoring Cys-341 to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation.
    Phosphorylated by PKA and BARK upon agonist stimulation, which mediates homologous desensitization of the receptor. PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK. Phosphorylated upon DNA damage, probably by ATM or ATR.
    Phosphorylation of Tyr-141 is induced by insulin and leads to supersensitization of the receptor.
    Ubiquitinated. Agonist-induced ubiquitination leads to sort internalized receptors to the lysosomes for degradation. Deubiquitination by USP20 and USP33, leads to ADRB2 recycling and resensitization after prolonged agonist stimulation. USP20 and USP33 are constitutively associated and are dissociated immediately after agonist stimulation.
  • 細胞内局在Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ADRB2 antibody
    • ADRB2_HUMAN antibody
    • ADRB2R antibody
    • ADRBR antibody
    • Adrenergic beta 2 receptor surface antibody
    • Adrenoceptor beta 2 surface antibody
    • B2AR antibody
    • BAR antibody
    • beta 2 adrenoceptor antibody
    • Beta 2 adrenoreceptor antibody
    • Beta-2 adrenergic receptor antibody
    • Beta-2 adrenoceptor antibody
    • Beta-2 adrenoreceptor antibody
    • BETA2AR antibody
    • Catecholamine receptor antibody
    • OTTHUMP00000160386 antibody
    see all

Anti-beta 2 Adrenergic Receptor antibody 画像

  • All lanes : Anti-beta 2 Adrenergic Receptor antibody (ab69598) at 1/500 dilution

    Lane 1 : Extracts from HeLa cells
    Lane 2 : Extracts from HeLa cells with immunising peptide at 5 µg

    Lysates/proteins at 5 µg per lane.

    Predicted band size : 47 kDa
    Observed band size : 60 kDa (why is the actual band size different from the predicted?)
  • NIH/3T3 cells stained with ab69598 at 1/500 dilution, with and without the immunising peptide.

Anti-beta 2 Adrenergic Receptor antibody (ab69598) 使用論文

ab69598 has not yet been referenced specifically in any publications.

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