製品の概要

  • 製品名Anti-BCRP/ABCG2 antibody [BXP-34]
    BCRP/ABCG2 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [BXP-34] to BCRP/ABCG2
  • 特異性This antibody does not cross react with the human MDR1, MRP1, MRP2 or MRP5 gene products.
  • アプリケーション適用あり: ICC, IHC-Frmore details
    適用なし: WB
  • 種交差性
    交差種: Human
  • 免疫原

    BCRP over-expressing cell line MCF 7 MR.

  • エピトープInternal epitope.
  • 特記事項


    Breast Cancer Resistance Protein (BCRP) is a 70 kDa ATP-Binding Cassette membrane transport protein involved in multidrug resistance. BCRP may be over-expressed in cancer cell lines selected with doxorubicin / verapamil, topotecan or mitoxantrone.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab3379 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration.
  • 追加情報Is unsuitable for WB.
  • ターゲット情報

    • 機能Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.
    • 組織特異性Highly expressed in placenta. Low expression in small intestine, liver and colon.
    • 配列類似性Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
      Contains 1 ABC transmembrane type-2 domain.
      Contains 1 ABC transporter domain.
    • 翻訳後修飾Glycosylation-deficient ABCG2 is normally expressed and functional.
    • 細胞内局在Cell membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • ABC transporter antibody
      • ABC15 antibody
      • ABCG 2 antibody
      • ABCG2 antibody
      • ABCG2_HUMAN antibody
      • ABCP antibody
      • ATP binding cassette sub family G (WHITE) member 2 antibody
      • ATP binding cassette transporter G2 antibody
      • ATP-binding cassette sub-family G member 2 antibody
      • BCRP antibody
      • BCRP1 antibody
      • BMDP antibody
      • Breast cancer resistance protein antibody
      • CD338 antibody
      • CDw338 antibody
      • CDw338 antigen antibody
      • EST157481 antibody
      • GOUT1 antibody
      • MGC102821 antibody
      • Mitoxantrone resistance associated protein antibody
      • Mitoxantrone resistance-associated protein antibody
      • MRX antibody
      • Multi drug resistance efflux transport ATP binding cassette sub family G (WHITE) member 2 antibody
      • MXR antibody
      • MXR1 antibody
      • Placenta specific ATP binding cassette transporter antibody
      • Placenta specific MDR protein antibody
      • Placenta-specific ATP-binding cassette transporter antibody
      • UAQTL1 antibody
      see all

    Anti-BCRP/ABCG2 antibody [BXP-34] (ab3379) 使用論文

    This product has been referenced in:
    • Scheffer GL  et al. Breast cancer resistance protein is localized at the plasma membrane in mitoxantrone- and topotecan-resistant cell lines. Cancer Res 60:2589-93 (2000). ICC/IF, IHC-Fr ; Human . Read more (PubMed: 10825126) »

    See 1 Publication for this product

    Product Wall

    Thank you for contacting us.

    I was unable to obtain the exact sequence of the peptide that was used as the immunogen for ab134707, and as far as we know, the epitope recognized by ab3379 has not been mapped. However, we do know that the immu...

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    Thank you for your inquiry.

    I have checked the immunogen sequences of the BCRP/ABCG2 and p53 antibodies we have that are tested in IHC-Fr with the rabbit sequences for these proteins.

    I am sorry to confirm that regrettably, the al...

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    The IgG concentration of ab3379 is approximately 0.25 mg/ml.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"