製品の概要

  • 製品名Anti-Bcr antibody
    Bcr 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Bcr
  • アプリケーション適用あり: IHC-P, ICC/IF, IPmore details
    適用なし: Flow Cyt or WB
  • 種交差性
    交差種: Human
    非交差種: Mouse, Rat
  • 免疫原

    Synthetic peptide within Human Bcr aa 1250-1350 (C terminal). The exact sequence is proprietary.

  • ポジティブ・コントロール
    • Jurkat cell lysate, human lung carcinoma and HeLa cells.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab32523 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P
ICC/IF
IP
  • 追加情報ICC/IF: 1/250 - 1/500.
    IHC-P: 1/100 - 1/250.
    IP: 1/40.


    Is unsuitable for FACS or WB.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.
    • 関連疾患Note=A chromosomal aberration involving BCR is a cause of chronic myeloid leukemia. Translocation t(9;22)(q34;q11) with ABL1. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).
    • 配列類似性Contains 1 C2 domain.
      Contains 1 DH (DBL-homology) domain.
      Contains 1 PH domain.
      Contains 1 Rho-GAP domain.
    • ドメインThe region involved in binding to ABL1 SH2-domain is rich in serine residues and needs to be Ser/Thr phosphorylated prior to SH2 binding. This region is essential for the activation of the ABL1 tyrosine kinase and transforming potential of the chimeric BCR-ABL oncogene.
      The DH domain is involved in interaction with CCPG1.
    • 翻訳後修飾Autophosphorylated. Phosphorylated by FES/FPS on tyrosine residues, leading to down-regulation of the BCR kinase activity. Phosphorylation at Tyr-177 by HCK is important for interaction with GRB2.
    • Information by UniProt
    • 参照データベース
    • 別名
      • ALL antibody
      • bcr antibody
      • BCR/ABL FUSION GENE, INCLUDED antibody
      • BCR/FGFR1 chimera protein antibody
      • BCR/FGFR1 FUSION GENE, INCLUDED antibody
      • BCR/PDGFRA FUSION GENE, INCLUDED antibody
      • BCR_HUMAN antibody
      • BCR1 antibody
      • Breakpoint cluster region antibody
      • Breakpoint cluster region protein antibody
      • CML antibody
      • D22S11 antibody
      • D22S662 antibody
      • FGFR1/BCR chimera protein antibody
      • PHL antibody
      • Renal carcinoma antigen NY-REN-26 antibody
      see all

    Anti-Bcr antibody 画像

    • Immunohistochemical analysis of paraffin-embedded human lung carcinoma using ab32523 at 1/100 dilution.Immunohistochemical analysis of paraffin-embedded human lung carcinoma using ab32523 at 1/100 dilution.
    • Immunofluorescent staining of HeLa cells using ab32523 at 1/250 dilution.

    Anti-Bcr antibody (ab32523) 使用論文

    ab32523 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab32523.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"