製品の概要

  • 製品名Anti-BCOR antibody
    BCOR 一次抗体 製品一覧
  • 製品の詳細
    Mouse polyclonal to BCOR
  • アプリケーション適用あり: WB, ICC/IFmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant full length Human BCOR (short isoform, NP_065977.1)

  • ポジティブ・コントロール
    • Human colon tissue lysate. HeLa cells.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab88112 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
ICC/IF
  • 追加情報ICC/IF: Use at a concentration of 10 µg/ml.
    WB: Use at a concentration of 1 µg/ml. Predicted molecular weight: 107 kDa (short isoform).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).
    • 組織特異性Ubiquitously expressed.
    • 関連疾患Defects in BCOR are the cause of microphthalmia syndromic type 2 (MCOPS2) [MIM:300166]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS2 is a very rare multiple congenital anomaly syndrome characterized by eye anomalies (congenital cataract, microphthalmia, or secondary glaucoma), facial abnormalities (long narrow face, high nasal bridge, pointed nose with cartilages separated at the tip, cleft palate, or submucous cleft palate), cardiac anomalies (atrial septal defect, ventricular septal defect, or floppy mitral valve) and dental abnormalities (canine radiculomegaly, delayed dentition, oligodontia, persistent primary teeth, or variable root length).
    • 配列類似性Belongs to the BCOR family.
      Contains 3 ANK repeats.
    • 細胞内局在Nucleus.
    • Information by UniProt
    • 参照データベース
    • 別名
      • 5830466J11Rik antibody
      • 8430401K06Rik antibody
      • ANOP 2 antibody
      • ANOP2 antibody
      • BCL 6 co repressor antibody
      • BCL 6 corepressor antibody
      • BCL 6 interacting corepressor antibody
      • BCL-6 corepressor antibody
      • BCL6 co repressor antibody
      • BCL6 corepressor antibody
      • BCL6 interacting corepressor antibody
      • BCoR antibody
      • BCOR_HUMAN antibody
      • FLJ20285 antibody
      • FLJ38041 antibody
      • KIAA1575 antibody
      • MAA 2 antibody
      • MAA2 antibody
      • MCOPS 2 antibody
      • MCOPS2 antibody
      • MGC131961 antibody
      • MGC71031 antibody
      see all

    Anti-BCOR antibody 画像

    • Anti-BCOR antibody (ab88112) at 1 µg/ml + Human colon tissue lysate at 50 µg

      Secondary
      Goat anti-Mouse IgG at 1/5000 dilution

      Predicted band size : 107 kDa
    • All lanes : Anti-BCOR antibody (ab88112) at 1 µg/ml

      Lane 1 : BCOR-transfected 293T cell lysate
      Lane 2 : untransfected 293T cell lysate

      Lysates/proteins at 25 µg per lane.

      Secondary
      Goat anti-Mouse IgG at 1/5000 dilution

      Predicted band size : 107 kDa
      Observed band size : 110 kDa (why is the actual band size different from the predicted?)
    • Immunofluorescence staining of BCOR in HeLa cells using ab88112 at 10 µg/ml followed by a fluorescein conjugated secondary antibody.

    Anti-BCOR antibody (ab88112) 使用論文

    This product has been referenced in:
    • Yoon J  et al. Interferon regulatory factor 8 (IRF8) interacts with the B cell lymphoma 6 (BCL6) corepressor BCOR. J Biol Chem 289:34250-7 (2014). ICC . Read more (PubMed: 25331958) »
    • Grossmann V  et al. Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype. Blood 118:6153-63 (2011). WB ; Human . Read more (PubMed: 22012066) »

    See all 2 Publications for this product

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