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Synthetic peptide (Human).
Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL1/THANK/zTNF4 and April/TALL2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non immunological cell growth. Three receptors, BCMA (for B cell maturation protein), TACI, and BAFFR, for BAFF were recently identified. BCMA, like TACI, binds BAFF and April. BAFF and its receptors induce B cell development and survival, activate NF-kappaB and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.
Our Abpromise guarantee covers the use of ab5972 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ICC/IF||Use a concentration of 20 µg/ml.|
|IHC-P||Use a concentration of 10 µg/ml.|
|WB||Use a concentration of 2 - 5 µg/ml. Predicted molecular weight: 20 kDa.Can be blocked with BCMA peptide (ab6087).|
Immunohistochemistry of BCMA in human spleen tissue with BCMA antibody at 5 µg/ml.
ab5972 at 10µg/ml staining BCMA in human spleen cells by IHC