製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to BCMA
  • アプリケーション
    適用あり: ICC/IF, IHC-P, WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide (Human).

  • ポジティブ・コントロール
    • Human spleen tissue lysate, K562 or U937 whole cell lysates.
  • 特記事項
    Stable for one year.


    Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL1/THANK/zTNF4 and April/TALL2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non immunological cell growth. Three receptors, BCMA (for B cell maturation protein), TACI, and BAFFR, for BAFF were recently identified. BCMA, like TACI, binds BAFF and April. BAFF and its receptors induce B cell development and survival, activate NF-kappaB and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C. Avoid freeze / thaw cycle. Stable for 12 months at -20°C.
  • バッファー
    Preservative: 0.02% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • 特記事項(精製)
    BCMA Antibody is affinity chromatography purified via peptide column.
  • 一次抗体 備考
    Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL1/THANK/zTNF4 and April/TALL2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non immunological cell growth. Three receptors, BCMA (for B cell maturation protein), TACI, and BAFFR, for BAFF were recently identified. BCMA, like TACI, binds BAFF and April. BAFF and its receptors induce B cell development and survival, activate NF-kappaB and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab5972 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF Use a concentration of 20 µg/ml.
IHC-P Use a concentration of 10 µg/ml.
WB Use a concentration of 2 - 5 µg/ml. Predicted molecular weight: 20 kDa.Can be blocked with BCMA peptide (ab6087).

ターゲット情報

  • 機能
    Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.
  • 組織特異性
    Expressed in mature B-cells, but not in T-cells or monocytes.
  • 関連疾患
    Note=A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.
  • 配列類似性
    Contains 1 TNFR-Cys repeat.
  • 細胞内局在
    Cell membrane. Endomembrane system. Perinuclear Golgi-like structures.
  • Information by UniProt
  • 参照データベース
  • 別名
    • B cell maturation antigen antibody
    • B cell maturation factor antibody
    • B cell maturation protein antibody
    • B-cell maturation protein antibody
    • BCM antibody
    • BCMA antibody
    • CD269 antibody
    • CD269 antigen antibody
    • TNFRSF17 antibody
    • TNR17_HUMAN antibody
    • Tumor necrosis factor receptor superfamily member 17 antibody
    see all

画像



  • Predicted band size : 20 kDa
    Western blot analysis of BCMA in human spleen (A) tissue lysate, K562 (B), and U937 (C) cell lysates with ab5972 at 5 µg/ml. Western blot analysis of BCMA in human spleen (A) tissue lysate, K562 (B), and U937 (C) cell lysates with ab5972 at 5 µg/ml.
  • ab5972 at 10µg/ml staining BCMA in human spleen cells by IHC

  • Immunofluorescence of BCMA in Human Spleen cells using ab5972 at 10 ug/ml.

  • Immunohistochemistry of BCMA in human spleen tissue with BCMA antibody at 5 µg/ml.

参考文献

This product has been referenced in:
  • Dou H  et al. APRIL, BCMA and TACI proteins are abnormally expressed in non-small cell lung cancer. Oncol Lett 12:3351-3355 (2016). WB, IHC-P ; Human . Read more (PubMed: 27900003) »
  • Osório C  et al. Selective regulation of axonal growth from developing hippocampal neurons by tumor necrosis factor superfamily member APRIL. Mol Cell Neurosci 59:24-36 (2014). IHC-Fr ; Mouse . Read more (PubMed: 24444792) »

See all 4 Publications for this product

レビューと Q&A

The immunogen is from the C-terminal region of BCMA, so the antibody binds the intracellular domain.

Thank you for contacting us.
This product has not been tested in mouse samples but it is unlikely to react, as the immunogen has very low homology with mouse.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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