製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to Bcl6
  • 特異性
    Detects 80-100 kDa Bcl-6 of human, mouse, and rat origins.
  • アプリケーション
    適用あり: IHC-Fr, WB, IP, Flow Cytmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide mapping to the C terminus of human Bcl6.

法規制情報

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab19011 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-Fr Use a concentration of 20 - 40 µg/ml.
WB Use a concentration of 1 - 4 µg/ml. Predicted molecular weight: 79 kDa.
IP Use a concentration of 5 - 10 µg/ml.
Flow Cyt Use at an assay dependent concentration. PubMed: 17982069ab171870-Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.

ターゲット情報

  • 機能
    Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.
  • 組織特異性
    Expressed in germinal center T and B cells and in primary immature dendritic cells.
  • 関連疾患
    Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions.
    Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1.
    Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.
  • 配列類似性
    Contains 1 BTB (POZ) domain.
    Contains 6 C2H2-type zinc fingers.
  • ドメイン
    The BTB domain mediates homodimerization. Its dimer interface mediates peptide binding such as to corepressors BCOR and NCOR2.
  • 翻訳後修飾
    Phosphorylated by MAPK1 in response to antigen receptor activation. Phosphorylation induces its degradation by ubiquitin/proteasome pathway.
  • 細胞内局在
    Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • B cell CLL/lymphoma 6 antibody
    • B cell lymphoma 6 protein antibody
    • B-cell lymphoma 5 protein antibody
    • B-cell lymphoma 6 protein antibody
    • BCL 5 antibody
    • Bcl 6 antibody
    • BCL-5 antibody
    • BCL-6 antibody
    • BCL5 antibody
    • BCL6 antibody
    • BCL6_HUMAN antibody
    • BCL6A antibody
    • cys his2 zinc finger transcription factor antibody
    • LAZ 3 antibody
    • LAZ 3 protein antibody
    • LAZ3 antibody
    • Lymphoma Associated Zinc Finger Gene On Chromosome 3 (LAZ3) antibody
    • Lymphoma associated zinc finger gene on chromosome 3 antibody
    • Protein LAZ-3 antibody
    • ZBTB 27 antibody
    • ZBTB27 antibody
    • Zinc finger and BTB domain containing protein 27 antibody
    • Zinc finger and BTB domain-containing protein 27 (ZBTB27) antibody
    • Zinc finger and BTB domain-containing protein 27 antibody
    • Zinc Finger Protein 51 (ZNF51) antibody
    • Zinc finger protein 51 antibody
    • zinc finger transcription factor BCL6S antibody
    • ZNF 51 antibody
    • ZNF51 antibody
    see all

画像



  • Predicted band size : 79 kDa

    Western blot analysis of Bcl-6 in Jurkat cell lysate using ab19011. Western blot analysis of Bcl-6 in Jurkat cell lysate using ab19011.

参考文献

This product has been referenced in:
  • Pei Y  et al. An essential EBV latent antigen 3C binds Bcl6 for targeted degradation and cell proliferation. PLoS Pathog 13:e1006500 (2017). Read more (PubMed: 28738086) »
  • Hu X  et al. Identification of zinc finger protein Bcl6 as a novel regulator of early adipose commitment. Open Biol 6:N/A (2016). WB . Read more (PubMed: 27251748) »

See all 7 Publications for this product

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