Anti-Bcl3 抗体 [Ham150-3.5] (ab15046)

製品の概要

• 製品名Anti-Bcl3 antibody [Ham150-3.5]
  Bcl3 一次抗体 製品一覧
• 製品の詳細
  Hamster monoclonal [Ham150-3.5] to Bcl3
• 特異性ab15046 recognises Bcl3 from transfected cells and shows no cross reactivity to other Bcl isoforms.
• アプリケーション適用あり: ELISA, WBmore details
• 種交差性
  交差種: Mouse, Human
  
• 免疫原

  Full length protein corresponding to Mouse Bcl3.

• ポジティブ･コントロール
  • C57BI/6 human T cells and Bcl3 transgenic ms T cells.

製品の特性

• 製品の状態Liquid
• 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• バッファーPreservative: 0.05% Sodium azide
  Constituents: 99% PBS, 0.1% BSA
• Concentration information loading...
• 精製度Protein G purified
• ポリ/モノモノクローナル
• クローン名Ham150-3.5
• アイソタイプIgG
• 研究分野
  • Immunology
  • Adaptive Immunity
  • B Cells
  • Non-CD

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Cancer susceptibility
  • Proto-oncogenes

  • Epigenetics and Nuclear Signaling
  • Nuclear Signaling Pathways
  • NFkB pathway

アプリケーション

ターゲット情報

• 機能Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation.
• 関連疾患Note=A chromosomal aberration involving BCL3 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(14;19)(q32;q13.1) with immunoglobulin gene regions.
• 配列類似性Contains 7 ANK repeats.
• 翻訳後修飾Polyubiquitinated. Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains. Deubiquitination by CYLD prevents nuclear accumulation.
  Activated by phosphorylation.
• 細胞内局在Nucleus. Cytoplasm. Cytoplasm > perinuclear region. Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation.

• Target information above from: UniProt accession P20749 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 602 Human
  • Entrez Gene: 12051 Mouse
  • Omim: 109560 Human
  • SwissProt: P20749 Human
  • SwissProt: Q9Z2F6 Mouse
  • Unigene: 31210 Human
• 別名
  • B cell CLL/lymphoma 3 antibody
  • B cell leukemia/lymphoma 3 antibody
  • B cell lymphoma 3 encoded protein antibody

  • B-cell lymphoma 3 protein antibody
  • Bcl 3 antibody
  • BCL 4 antibody
  • BCL-3 antibody
  • Bcl3 antibody
  • BCL3_HUMAN antibody
  • BCL4 antibody
  • Chronic lymphatic leukemia protein antibody
  • D19S37 antibody
  • Protein Bcl 3 antibody
  • Proto-oncogene BCL3 antibody

  see all