製品の概要
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製品名Anti-Bcl3 antibody [Ham150-3.5]
Bcl3 一次抗体 製品一覧 -
製品の詳細Hamster monoclonal [Ham150-3.5] to Bcl3
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由来種Hamster
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特異性ab15046 recognises Bcl3 from transfected cells and shows no cross reactivity to other Bcl isoforms.
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アプリケーション適用あり: ELISA, WBmore details
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種交差性交差種: Mouse, Human
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免疫原
Full length protein corresponding to Mouse Bcl3.
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ポジティブ･コントロール
- C57BI/6 human T cells and Bcl3 transgenic ms T cells.
製品の特性
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製品の状態Liquid
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保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
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バッファーPreservative: 0.05% Sodium azide
Constituents: 99% PBS, 0.1% BSA -
Concentration information loading... -
精製度Protein G purified
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ポリ/モノモノクローナル
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クローン名Ham150-3.5
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アイソタイプIgG
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研究分野
アプリケーション
Our Abpromise guarantee covers the use of ab15046 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| ELISA | Use at an assay dependent dilution. | |
| WB | Use a concentration of 2 µg/ml. Detects a band of approximately 47 kDa (predicted molecular weight: 50 kDa). |
ターゲット情報
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機能Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation.
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関連疾患Note=A chromosomal aberration involving BCL3 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(14;19)(q32;q13.1) with immunoglobulin gene regions.
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配列類似性Contains 7 ANK repeats.
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翻訳後修飾Polyubiquitinated. Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains. Deubiquitination by CYLD prevents nuclear accumulation.
Activated by phosphorylation. -
細胞内局在Nucleus. Cytoplasm. Cytoplasm > perinuclear region. Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation.
- Information by UniProt
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参照データベース
- Entrez Gene: 602 Human
- Entrez Gene: 12051 Mouse
- Omim: 109560 Human
- SwissProt: P20749 Human
- SwissProt: Q9Z2F6 Mouse
- Unigene: 31210 Human
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別名
- B cell CLL/lymphoma 3 antibody
- B cell leukemia/lymphoma 3 antibody
- B cell lymphoma 3 encoded protein antibody
see all
画像
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![Western blot - Anti-Bcl3 antibody [Ham150-3.5] (ab15046)](http://a.abcam.com/ps/products/15/ab15046/Images/various.jpg)
Western blot - Anti-Bcl3 antibody [Ham150-3.5] (ab15046)Anti-Bcl3 antibody [Ham150-3.5] (ab15046) at 2 µg/ml
Predicted band size: 50 kDa
Western blot of Bcl3 in transgenic mouse T cells using Ab15046.
プロトコール
参考文献
ab15046 has not yet been referenced specifically in any publications.
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"