製品の概要

  • 製品名Anti-Bcl-XL antibody
    Bcl-XL 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Bcl-XL
  • 特異性Antibody detects endogenous levels of Bcl-xL protein around Serine 62.
  • アプリケーション適用あり: WB, IHC-P, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic peptide corresponding to Human Bcl-XL.
    Database link: Q07817

  • ポジティブ・コントロール
    • Breast carcinoma tissue, extracts of 293 cells treated with UV and extracts of MDA-MB-435 cells treated with UV.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab31396 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Predicted molecular weight: 26 kDa.
IHC-P Use at an assay dependent concentration.
ELISA 1/10000.

ターゲット情報

  • 機能Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane.
    Isoform Bcl-X(S) promotes apoptosis.
  • 組織特異性Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain.
  • 配列類似性Belongs to the Bcl-2 family.
  • ドメインThe BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death.
  • 翻訳後修飾Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity.
  • 細胞内局在Mitochondrion membrane. Nucleus membrane. Mitochondrial membranes and perinuclear envelope.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Apoptosis regulator Bcl X antibody
    • Apoptosis regulator Bcl-X antibody
    • Apoptosis regulator BclX antibody
    • B cell lymphoma 2 like antibody
    • B2CL1_HUMAN antibody
    • Bcl 2 like 1 protein antibody
    • Bcl X antibody
    • Bcl xL antibody
    • BCL XL/S antibody
    • Bcl xS antibody
    • Bcl-2-like protein 1 antibody
    • Bcl2 Like 1 antibody
    • Bcl2 related gene antibody
    • Bcl2-L-1 antibody
    • BCL2L antibody
    • Bcl2l1 antibody
    • BCLX antibody
    • BclXL antibody
    • BclXs antibody
    • DKFZp781P2092 antibody
    • PPP1R52 antibody
    • Protein phosphatase 1 regulatory subunit 52 antibody
    see all

Anti-Bcl-XL antibody 画像

  • ab31396 at a 1/50-1/100 dilution staining Bcl-XL in human breast carcinoma tissue by Immunohistochemistry, Paraffin Embedded Tissue.

    Left image : Un-treated.

    Right image : Antibody pre-incubated with synthesized peptide.

  • All lanes : Anti-Bcl-XL antibody (ab31396) at 1/500 dilution

    Lane 1 : Extracts of 293 cells treated with UV (5 to 30ug of total protein).
    Lane 2 : Extracts of MDA-MB-435 cells treated with UV (5 to 30ug of total protein).


    Predicted band size : 26 kDa

Anti-Bcl-XL antibody (ab31396) 使用論文

ab31396 has not yet been referenced specifically in any publications.

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The band is predicted to be 26 kDa based on the amino acid sequence, but post-translational modifications ...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"