製品の概要

  • 製品名Anti-Bcl-XL antibody
    Bcl-XL 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Bcl-XL
  • 特異性This antibody cross-reacts with Bcl xS.
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Human
    交差が予測される動物種: Rat, Sheep, Rabbit, Cat, Dog, Pig
  • 免疫原

    Synthetic peptide corresponding to Human Bcl-XL aa 3-14.
    Sequence:

    QSNRELVVDFLS


    Database link: Q07817

  • ポジティブ・コントロール
    • Jurkat human T cells, MOLT4 human leukemia cells or Rh30 human rhabdomyosarcoma cells.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab13891 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 28 kDa.

ターゲット情報

  • 機能Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane.
    Isoform Bcl-X(S) promotes apoptosis.
  • 組織特異性Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain.
  • 配列類似性Belongs to the Bcl-2 family.
  • ドメインThe BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death.
  • 翻訳後修飾Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity.
  • 細胞内局在Mitochondrion membrane. Nucleus membrane. Mitochondrial membranes and perinuclear envelope.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Apoptosis regulator Bcl X antibody
    • Apoptosis regulator Bcl-X antibody
    • Apoptosis regulator BclX antibody
    • B cell lymphoma 2 like antibody
    • B2CL1_HUMAN antibody
    • Bcl 2 like 1 protein antibody
    • Bcl X antibody
    • Bcl xL antibody
    • BCL XL/S antibody
    • Bcl xS antibody
    • Bcl-2-like protein 1 antibody
    • Bcl2 Like 1 antibody
    • Bcl2 related gene antibody
    • Bcl2-L-1 antibody
    • BCL2L antibody
    • Bcl2l1 antibody
    • BCLX antibody
    • BclXL antibody
    • BclXs antibody
    • DKFZp781P2092 antibody
    • PPP1R52 antibody
    • Protein phosphatase 1 regulatory subunit 52 antibody
    see all

Anti-Bcl-XL antibody 画像

  • Western blot analysis of Bcl-xL using ab13891 at 2 µg/ml against 20 µg of Rh30 cell lysate.

    Western blot analysis of Bcl-xL using ab13891 at 2 µg/ml against 20 µg of Rh30 cell lysate.

Anti-Bcl-XL antibody (ab13891) 使用論文

ab13891 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"