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機能
Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.
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組織特異性
Widely expressed with an abundant expression in the testis. Low level of expression seen in the liver, thymus, and peripheral blood leukocytes. The protein has been detected in a B-cell line.
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配列類似性
Belongs to the CAS family.
Contains 1 SH3 domain.
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ドメイン
Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL1 SH2 domains. The HLH motif is absolutely required for the induction of pseudohyphal growth in yeast and mediates heterodimerization with NEDD9.
A serine-rich region promotes activation of the serum response element (SRE).
The SH3 domain is necessary for the localization of the protein to focal adhesions and interacts with one proline-rich region of PTK2/FAK11.
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翻訳後修飾
PTK2/FAK1 activation mediates phosphorylation at the YDYVHL motif; phosphorylation is most likely catalyzed by SRC family members. SRC-family kinases are recruited to the phosphorylated sites and can phosphorylate other tyrosine residues. Tyrosine phosphorylation is triggered by integrin-mediated adhesion of cells to the extracellular matrix.
Dephosphorylated by PTPN14 at Tyr-128.
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細胞内局在
Cell junction, focal adhesion. Cytoplasm. Unphosphorylated form localizes in the cytoplasm and can move to the membrane upon tyrosine phosphorylation.
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Information by UniProt
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参照データベース
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別名
- BCAR 1 antibody
- Bcar1 antibody
- BCAR1_HUMAN antibody
- Breast cancer anti estrogen resistance 1 antibody
- Breast cancer anti estrogen resistance 1 protein antibody
- Breast cancer anti-estrogen resistance protein 1 antibody
- CAS antibody
- Cas scaffolding protein family member 1 antibody
- CAS1 antibody
- Cass1 antibody
- Crk associated substrate antibody
- Crk associated substrate p130Cas antibody
- CRK-associated substrate antibody
- CRKAS antibody
- FLJ12176 antibody
- FLJ45059 antibody
- p130cas antibody
see all