製品の概要

  • 製品名Anti-BAP1 antibody - C-terminal
    BAP1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to BAP1 - C-terminal
  • アプリケーション適用あり: ELISA, WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide within Human BAP1 aa 699-729 (C terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.

  • ポジティブ・コントロール
    • SK-BR-3 cell lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab71642 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/1000.
WB 1/100 - 1/500. Detects a band of approximately 81 kDa (predicted molecular weight: 81 kDa).

ターゲット情報

  • 機能Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Acts as a tumor suppressor.
  • 組織特異性Highly expressed in testis, placenta and ovary. Expressed in breast.
  • 配列類似性Belongs to the peptidase C12 family. BAP1 subfamily.
  • 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 細胞内局在Cytoplasm. Nucleus. Mainly nuclear. Binds to chromatin.
  • Information by UniProt
  • 参照データベース
  • 別名
    • BAP 1 antibody
    • Bap1 antibody
    • BAP1_HUMAN antibody
    • BRCA 1 associated protein 1 antibody
    • BRCA1 associated protein 1 antibody
    • BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) antibody
    • BRCA1-associated protein 1 antibody
    • Cerebral protein 13 antibody
    • Cerebral protein 6 antibody
    • DKFZp686N04275 antibody
    • FLJ35406 antibody
    • FLJ37180 antibody
    • HUCEP 13 antibody
    • Hucep 6 antibody
    • HUCEP13 antibody
    • Hucep6 antibody
    • KIAA0272 antibody
    • TPDS antibody
    • Ubiquitin carboxy terminal hydrolase antibody
    • Ubiquitin carboxyl terminal hydrolase BAP 1 antibody
    • Ubiquitin carboxyl terminal hydrolase BAP1 antibody
    • Ubiquitin carboxyl-terminal hydrolase BAP1 antibody
    • UCHL2 antibody
    see all

Anti-BAP1 antibody - C-terminal 画像

  • Anti-BAP1 antibody - C-terminal (ab71642) at 1/100 dilution + SK-BR-3 cell lysate at 12.5 µg

    Predicted band size : 81 kDa
    Observed band size : 81 kDa
    Additional bands at : 30 kDa,60 kDa. We are unsure as to the identity of these extra bands.

Anti-BAP1 antibody - C-terminal (ab71642) 使用論文

ab71642 has not yet been referenced specifically in any publications.

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