製品の概要

  • 製品名BAN ORL 24
  • 製品の詳細
    Potent, selective ORL1 non-peptide agonist
  • 生理活性の詳細Potent, selective, competitive ORL1 non-peptide agonist. Displays 1000-fold selectivity over classical opioid receptors. IC50 values for receptor subtypes are 0.27 (ORL1), 6700 (μ), 2500 (κ) and >10000 (δ) nM. Systemic administration alleviates experimental Parkinson's in rats.
  • 精製度> 95%

製品の特性

  • 体系名(2R)-1-(Phenylmethyl)-N-(3-spiro[isobenzofuran-1(3H)-4'-piperidin]-1-ylpropyl)-2-pyrrolidinecarboxamide dihydrochloride
  • 分子量506.51
  • 構造式Chemical Structure
  • 分子式C27H35N3O2.2HCl
  • CAS 番号1401463-54-4
  • 保存方法Store at -20°C. It is important to note that this is air sensitive and impurities can occur as a result of air oxidation. Store under Desiccating conditions.
  • 溶解性Soluble in water to 100 mM and in DMSO to 100 mM
  • 使用に関する注意

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • 由来

    Synthetic

  • 研究分野

    BAN ORL 24 (ab120671) 使用論文

    This product has been referenced in:
    • Volta M  et al. Dopamine-nociceptin/orphanin FQ interactions in the substantia nigra reticulata of hemiparkinsonian rats: involvement of D2/D3 receptors and impact on nigro-thalamic neurons and motor activity. Exp Neurol 228:126-37 (2011). Read more (PubMed: 21215744) »

    See all 3 Publications for this product

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