製品の概要

  • 製品名Anti-Bag3 antibody
    Bag3 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to Bag3
  • アプリケーション適用あり: IP, WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide: SSMTDTPGNPAAP, corresponding to C terminal amino acids 563-575 of Human Bag3.

  • ポジティブ・コントロール
    • Human skeletal muscle lysates.
  • 特記事項GenBank Accession Number – NP_004272

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab5898 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IP Use at an assay dependent concentration. PubMed: 23341456
WB Use a concentration of 0.1 - 0.3 µg/ml. Can be blocked with Human Bag3 peptide (ab23111).
Approx 85kDa band observed in Human skeletal muscle lysates (calculated MW of 61.6kDa according to NP_004272.2). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Iwasaki et al, Cancer Res. 2007 Nov 1;67(21):10252-9. PMID: 17974966).

ターゲット情報

  • 機能Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity.
  • 関連疾患Defects in BAG3 are the cause of myopathy myofibrillar BAG3-related (MFM-BAG3) [MIM:612954]. A neuromuscular disorder that results in early-onset, severe, progressive, diffuse muscle weakness associated with cardiomyopathy, severe respiratory insufficiency during adolescence, and a rigid spine in some patients. At ultrastructural level, muscle fibers display structural alterations consisting of replacement of the normal myofibrillar markings by small, dense granules, or larger hyaline masses, or amorphous material.
  • 配列類似性Contains 1 BAG domain.
    Contains 2 WW domains.
  • Information by UniProt
  • 参照データベース
  • 別名
    • BAG 3 antibody
    • BAG family molecular chaperone regulator 3 antibody
    • BAG-3 antibody
    • Bag3 antibody
    • BAG3_HUMAN antibody
    • Bcl 2 binding protein antibody
    • Bcl-2-associated athanogene 3 antibody
    • Bcl-2-binding protein Bis antibody
    • BCL2 associated athanogene 3 antibody
    • BCL2 binding athanogene 3 antibody
    • BIS antibody
    • CAIR 1 antibody
    • Docking protein CAIR 1 antibody
    • Docking protein CAIR-1 antibody
    • MFM6 antibody
    see all

Anti-Bag3 antibody (ab5898) 使用論文

This product has been referenced in:
  • Boiani M  et al. The stress protein BAG3 stabilizes Mcl-1 protein and promotes survival of cancer cells and resistance to antagonist ABT-737. J Biol Chem 288:6980-90 (2013). IP ; Human . Read more (PubMed: 23341456) »

See 1 Publication for this product

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Thank you for providing more information about your protocol. We would like to emphasize that this is a Fast-Track antibody and not fully characterized yet. Please take a look at the Terms and Conditions for Fast-Track products. We cannot guarant...

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