Anti-BAFF Receptor 抗体 [11C1] (Biotin) (ab16582)
製品の概要
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製品名Anti-BAFF Receptor antibody [11C1] (Biotin)
BAFF Receptor 一次抗体 製品一覧 -
製品の詳細Mouse monoclonal [11C1] to BAFF Receptor (Biotin)
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由来種Mouse
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標識Biotin
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アプリケーション適用あり: Flow Cyt, IHC-Fr, IHC-Pmore details
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種交差性交差種: Human
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免疫原
Tissue/ cell preparation (Human) - human BAFF Receptor transfected mouse B cell lymphoma L1.2 cells.
製品の特性
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製品の状態Liquid
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保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
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Concentration information loading... -
精製度Protein G purified
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ポリ/モノモノクローナル
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クローン名11C1
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ミエローマSp2/0
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アイソタイプIgG1
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研究分野
関連製品
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Alternative Versions
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Compatible Secondaries
アプリケーション
Our Abpromise guarantee covers the use of ab16582 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| Flow Cyt | ||
| IHC-Fr | ||
| IHC-P |
追加情報
Flow Cyt: Use at an assay dependent dilution.
IHC-P: Use at an assay dependent dilution. Antigen retrieval with EDTA based solution (pH9.0) and heat.
IHC-Fr: Use at an assay dependent dilution.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
IHC-P: Use at an assay dependent dilution. Antigen retrieval with EDTA based solution (pH9.0) and heat.
IHC-Fr: Use at an assay dependent dilution.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
ターゲット情報
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機能B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.
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組織特異性Highly expressed in spleen and lymph node, and in resting B-cells. Detected at lower levels in activated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes.
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関連疾患Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4) [MIM:613494]; also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.
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配列類似性Contains 1 TNFR-Cys repeat.
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細胞内局在Membrane.
- Information by UniProt
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参照データベース
- Entrez Gene: 115650 Human
- Omim: 606269 Human
- SwissProt: Q96RJ3 Human
- Unigene: 344088 Human
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別名
- B cell activating factor receptor antibody
- B-cell-activating factor receptor antibody
- BAFF R antibody
see all
参考文献
This product has been referenced in:
- Xu H et al. Abnormally high expression of BAFF on T lymphocytes from lung cancer-associated pleural effusions and its potent anti-tumor effect. Acta Biochim Biophys Sin (Shanghai) 39:964-73 (2007). Flow Cyt ; Human . Read more (PubMed: 18064389) »
- Ng LG et al. B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells. J Immunol 173:807-17 (2004). Read more (PubMed: 15240667) »
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"