Anti-Bacillus anthracis lethal factor 抗体 [BAL0105] (HRP) (ab24451)

製品の概要

  • 製品名Anti-Bacillus anthracis lethal factor antibody [BAL0105] (HRP)
    Bacillus anthracis lethal factor 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [BAL0105] to Bacillus anthracis lethal factor (HRP)
  • 標識HRP
  • 特異性Lethal factor antigen of Bacillus anthracis.
  • アプリケーション適用あり: Sandwich ELISA, ELISAmore details
  • 種交差性
    Reacts with Bacillus anthracis. Not yet tested in other species.
  • 免疫原

    Highly purified lethal factor antigen of Bacillus anthracis.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C.
  • バッファーpH: 7.40
    Constituents: PBS, 50% Glycerol
  • Concentration information loading...
  • 精製度Protein G purified
  • ポリ/モノモノクローナル
  • クローン名BAL0105
  • ミエローマSp2/0
  • アイソタイプIgG1
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab24451 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Sandwich ELISA Use at an assay dependent dilution.
ELISA Use at an assay dependent dilution. Can be paired for ELISA with Mouse monoclonal [BAL0106] to Bacillus anthracis lethal factor (ab8243). Can be used as capture antibody

ターゲット情報

  • 関連性The protease enzyme Lethal Factor (LF) is one of the three proteins (LF, EF & PA) composing the anthrax toxin produced by Bacillus anthracis, a bacteria which can infect many mammalian species and that may be fatal. LF is not toxic by itself, but when associated with Protective Antigen (PA), can then gain entry to cells. Once inside the cell, LF then cleaves the N terminal of most dual specificity mitogen activated protein kinase kinases (MAPKKs or MAP2Ks) (except for MAP2K5). Cleavage invariably occurs within the N terminal proline rich region preceding the kinase domain, thus disrupting a sequence involved in directing specific protein protein interactions necessary for the assembly of signaling complexes. There may be other cytosolic targets of LF involved in cytotoxicity. The proteasome may mediate a toxic process initiated by LF in the cell cytosol involving degradation of unidentified molecules that are essential for macrophage homeostasis. This is an early step in LF intoxication, but it is downstream of the cleavage by LF of MEK1 or other putative substrates.
  • 細胞内局在secreted
  • 別名
    • Anthrax lethal toxin endopeptidase component antibody
    • Anthrax LF antibody
    • Lef antibody
    • Lethal factor antibody
    • LF antibody
    see all

Anti-Bacillus anthracis lethal factor antibody [BAL0105] (HRP) (ab24451) 使用論文

ab24451 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting us.

I have had the oportunity to look over the data regarding the antibodies we had talked about this morning. I am confident that your assessment of those products we correct as ab8242 and ab24451 have been created ...

Read More

Thank you for calling Abcam yesterday. I think there is an error in the datasheet for ab24451, I do not think there is sodium azide in the storage buffer. I am continuing to consult with my colleagues about this and I will contact you again, as soon as...

Read More

Thank you for your enquiry. Both ab8243 and ab24451 were generated using highly purified lethal factor antigen of Bacillus anthracis. These two antibodies can be used together in a sandwich ELISA where ab8243 is the coating antibody and ab24451 is the ...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"