Anti-BACH1/BRIP1 抗体 [3G11] (ab14383)


  • 製品名Anti-BACH1/BRIP1 antibody [3G11]
    BACH1/BRIP1 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [3G11] to BACH1/BRIP1
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fusion protein (C-terminus of Human BACH1).

  • ポジティブ・コントロール
    • MCF7, HeLa, 293 and U2OS cell lysates.



Our Abpromise guarantee covers the use of ab14383 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 82 kDa.


  • 機能DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1.
  • 組織特異性Ubiquitously expressed, with highest levels in testis.
  • 関連疾患Defects in BRIP1 are a cause of susceptibility to breast cancer (BC) [MIM:114480]. A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case.
    Defects in BRIP1 are the cause of Fanconi anemia complementation group J (FANCJ) [MIM:609054]. It is a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
  • 配列類似性Belongs to the DEAD box helicase family. DEAH subfamily.
    Contains 1 helicase ATP-binding domain.
  • ドメイン4Fe-4S iron-sulfur-binding is required for helicase activity (PubMed:20639400).
  • 翻訳後修飾Phosphorylated. Phosphorylation is necessary for interaction with BRCA1, and is cell-cycle regulated.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ATP dependent RNA helicase BRIP1 antibody
    • ATP-dependent RNA helicase BRIP1 antibody
    • BACH 1 antibody
    • BRAC 1 Associated C Terminal Helicase 1 antibody
    • BRCA 1 Interacting Protein 1 antibody
    • BRCA1 binding helicase like protein BACH1 antibody
    • BRCA1 interacting protein C terminal helicase 1 antibody
    • BRCA1-associated C-terminal helicase 1 antibody
    • BRCA1-interacting protein 1 antibody
    • BRCA1-interacting protein C-terminal helicase 1 antibody
    • BRCA1/BRCA2 associated helicase 1 antibody
    • BRIP 1 antibody
    • BRIP1 antibody
    • FANCJ antibody
    • FANCJ_HUMAN antibody
    • Fanconi anemia group J protein antibody
    • FLJ90232 antibody
    • MGC126521 antibody
    • MGC126523 antibody
    • OF antibody
    • Protein FACJ antibody
    see all

Anti-BACH1/BRIP1 antibody [3G11] (ab14383) 使用論文

ab14383 has not yet been referenced specifically in any publications.

Product Wall

Application Western blot
Sample Human Cell lysate - whole cell (IMR90, 293, MCF7)
Specification IMR90, 293, MCF7
Blocking step Milk as blocking agent for 12 hour(s) and 0 minute(s) · Concentration: 5

Dr. Ron Drapkin

Verified customer

投稿 Aug 23 2005