製品の概要

製品の詳細

  • 由来Synthetic

関連製品

特性

Our Abpromise guarantee covers the use of ab5869 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking

  • 精製度> 95 % SDS-PAGE.

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

関連情報

  • 別名
    • ALP 56
    • ALP56
    • Asp 1
    • ASP1
    • ASP21
    • Aspartic Like Protease 56kDa
    • Aspartic-like protease 56 kDa
    • Aspartyl protease 1
    • BACE 2
    • Bace2
    • BACE2_HUMAN
    • Beta Secretase 2
    • Beta Site Amyloid Beta A4 Precursor Protein Cleaving Enzyme 2
    • Beta-secretase 2
    • Beta-site amyloid precursor protein cleaving enzyme 2
    • Beta-site APP cleaving enzyme 2
    • Down region aspartic protease
    • Downs Syndrome Region Aspartic Protease
    • DRAP
    • Memapsin 1
    • Memapsin-1
    • Membrane associated aspartic protease 1
    • Membrane-associated aspartic protease 1
    • Theta-secretase
    see all
  • 機能Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.
  • 組織特異性Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed at low levels in the brain. Found in spinal cord, medulla oblongata, substantia nigra and locus coruleus. Expressed in the ductal epithelium of both normal and malignant prostate.
  • 配列類似性Belongs to the peptidase A1 family.
  • 翻訳後修飾Undergoes autoproteolytic cleavage.
    Glycosylated.
  • 細胞内局在Membrane. Golgi apparatus. Endoplasmic reticulum. Endosome. Cell surface.
  • Information by UniProt

BACE2 peptide (ab5869) 使用論文

ab5869 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"