製品の概要

  • 製品名
    Anti-BACE1 antibody - N-terminal
    BACE1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to BACE1 - N-terminal
  • アプリケーション
    適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    Synthetic peptide (Human) conjugated to KLH from the N-terminus

  • ポジティブ・コントロール
    • Mouse heart tissue lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab79921 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/50 - 1/100. Detects a band of approximately 56 kDa (predicted molecular weight: 56 kDa).
ELISA 1/1000.

ターゲット情報

  • 機能
    Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
  • 組織特異性
    Expressed at high levels in the brain and pancreas. In the brain, expression is highest in the substantia nigra, locus coruleus and medulla oblongata.
  • 配列類似性
    Belongs to the peptidase A1 family.
  • ドメイン
    The transmembrane domain is necessary for its activity. It determines its late Golgi localization and access to its substrate, APP.
  • 翻訳後修飾
    Glycosylated.
  • 細胞内局在
    Membrane. Golgi apparatus > trans-Golgi network. Endoplasmic reticulum. Endosome. Cell surface. Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface.
  • Information by UniProt
  • 参照データベース
  • 別名
    • APP beta secretase antibody
    • Asp 2 antibody
    • ASP2 antibody
    • Aspartyl protease 2 antibody
    • BACE 1 antibody
    • BACE antibody
    • BACE1 antibody
    • BACE1_HUMAN antibody
    • Beta secretase 1 antibody
    • Beta secretase antibody
    • Beta site amyloid beta A4 precursor protein cleaving enzyme antibody
    • Beta site amyloid precursor protein cleaving enzyme 1 antibody
    • Beta site amyloid precursor protein cleaving enzyme antibody
    • Beta site APP cleaving enzyme 1 antibody
    • Beta site APP cleaving enzyme antibody
    • Beta-secretase 1 antibody
    • Beta-site amyloid precursor protein cleaving enzyme 1 antibody
    • Beta-site APP cleaving enzyme 1 antibody
    • FLJ90568 antibody
    • HSPC104 antibody
    • Memapsin 2 antibody
    • Memapsin-2 antibody
    • Memapsin2 antibody
    • Membrane associated aspartic protease 2 antibody
    • Membrane-associated aspartic protease 2 antibody
    • Transmembrane aspartic proteinase Asp2 antibody
    see all

画像

  • Anti-BACE1 antibody - N-terminal (ab79921) at 1/50 dilution + Mouse heart tissue lysate at 35 µg

    Predicted band size : 56 kDa
    Observed band size : 56 kDa
    Additional bands at : 35 kDa,40 kDa. We are unsure as to the identity of these extra bands.

プロトコール

参考文献

ab79921 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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