製品の概要

  • 製品名Anti-BAAT antibody
    BAAT 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to BAAT
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant protein fragment corresponding to a region within amino acids 139 - 385 of Human BAAT (NP_001692).

  • ポジティブ・コントロール
    • WB: 293T, HepG2 and Raji cell lysates IHC-P: SW480 xenograft

法規制情報

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab97455 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/3000. Predicted molecular weight: 46 kDa.
IHC-P 1/100 - 1/500.

ターゲット情報

  • 機能Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile acids, or both. The conjugation increases the detergent properties of bile acids in the intestine, which facilitates lipid and fat-soluble vitamin absorption. In turn, bile acids are deconjugated by bacteria in the intestine and are recycled back to the liver for reconjugation (secondary bile acids). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs.
  • 組織特異性Expressed in liver, gallbladder mucosa and pancreas.
  • 関連疾患Defects in BAAT are involved in familial hypercholanemia (FHCA) [MIM:607748]. FHCA is a disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption.
  • 配列類似性Belongs to the C/M/P thioester hydrolase family.
  • 細胞内局在Cytoplasm.
  • Information by UniProt
  • 参照データベース
  • 別名
    • FLJ20300 antibody
    • BAAT antibody
    • BAAT_HUMAN antibody
    • BACAT antibody
    • BAT antibody
    • Bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase) antibody
    • Bile acid CoA:amino acid N acyltransferase antibody
    • Bile acid Coenzyme A amino acid N acyltransferase glycine N choloyltransferase antibody
    • Bile acid Coenzyme A: amino acid N acyltransferase antibody
    • Bile acid-CoA:amino acid N-acyltransferase antibody
    • Glycine N choloyltransferase antibody
    • Glycine N-choloyltransferase antibody
    • Long chain fatty acyl CoA hydrolase antibody
    • Long-chain fatty-acyl-CoA hydrolase antibody
    • MGC104432 antibody
    see all

Anti-BAAT antibody 画像

  • Anti-BAAT antibody (ab97455) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

    Predicted band size : 46 kDa
  • ab97455, at a 1/100 dilution, staining BAAT in a paraffin-embedded SW480 xenograft by Immunohistochemical analysis.

Anti-BAAT antibody (ab97455) 使用論文

This product has been referenced in:
  • Chong CP  et al. Bile acid-CoA ligase deficiency--a new inborn error of bile acid metabolism. J Inherit Metab Dis 35:521-30 (2012). IHC-P ; Human . Read more (PubMed: 22089923) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"