製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to B4GALT1
  • アプリケーション
    適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    antigen, corresponding to amino acids 323-398 (FRGMSISRPN AVVGRCRMIR HSRDKKNEPN PQRFDRIAHT KETMLSDGLN SLTYQVLDVQ RYPLYTQITV DIGTPS) of Human B4GALT1.

  • ポジティブ・コントロール
    • Human lateral ventricle tissue.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファー
    pH: 7.20
    Preservative: 0.02% Sodium azide
    Constituents: 59% PBS, 40% Glycerol
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab121325 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/10 - 1/20. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能
    The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.
    The cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, as those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix.
  • 組織特異性
    Ubiquitously expressed, but at very low levels in fetal and adult brain.
  • パスウェイ
    Protein modification; protein glycosylation.
  • 関連疾患
    Defects in B4GALT1 are the cause of congenital disorder of glycosylation type 2D (CDG2D) [MIM:607091]. CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.
  • 配列類似性
    Belongs to the glycosyltransferase 7 family.
  • 翻訳後修飾
    The soluble form derives from the membrane forms by proteolytic processing.
  • 細胞内局在
    Golgi apparatus > Golgi stack membrane. Cell membrane. Cell surface. Found in trans cisternae of Golgi; Golgi apparatus > Golgi stack membrane. Found in trans cisternae of Golgi and Secreted. Soluble form found in body fluids.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 384.Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase antibody
    • 4-galactosyltransferase 1 antibody
    • 4-GalTase 1 antibody
    • b4Gal-T1 antibody
    • B4galt1 antibody
    • B4GT1_HUMAN antibody
    • Beta-1 antibody
    • Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase antibody
    • Beta4Gal-T1 antibody
    • CDG2D antibody
    • GGTB2 antibody
    • GT1 antibody
    • GTB antibody
    • Lactose synthase A protein antibody
    • N-acetyllactosamine synthase antibody
    • Nal synthase antibody
    • Processed beta-1 antibody
    • UDP-Gal:beta-GlcNAc beta-1 antibody
    • UDP-galactose:beta-N-acetylglucosamine beta-1 antibody
    see all

画像

  • ab121325, at 1/10, staining B4GALT1 in paraffin embedded Human lateral ventricle tissue by Immunohistochemistry.

プロトコール

参考文献

ab121325 has not yet been referenced specifically in any publications.

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