製品の概要

  • 製品名
    AZD4547
  • 製品の詳細
    Novel, selective FGFR inhibitor
  • 別名
    • AZD-4547
  • 生理活性の詳細

    Novel, selective inhibitor of the FGFR1, 2, and 3 tyrosine kinases. Binds to and inhibits FGFR, which may result in the inhibition of FGFR-related signal transduction pathways, thus resulting in the inhibition of tumor cell proliferation and tumor cell death. 

  • 精製度
    > 98%

製品の特性

  • 体系名

    N-(5-(3,5-dimethoxyphenethyl)-1H-pyrazol-3-yl)-4-((3S,5R)-3,5-dimethylpiperazin-1-yl)benzamide

  • 分子量
    463.57
  • 構造式
    Chemical Structure
  • 分子式
    C26H33N5O3
  • CAS 番号
    1035270-39-3
  • PubChem 登録番号
    51039095
  • 保存方法
    Shipped at 4°C. Store at -20°C. Store In the Dark. Store under desiccating conditions.
  • 溶解性

    DMSO (>80 mg/ml)

  • SMILES 線形表記
    O=C(Nc2cc(CCc1cc(OC)cc(OC)c1)nn2)c3ccc(cc3)N4C[C@H](C)N[C@H](C)C4

参考文献

This product has been referenced in:
  • Kwak Y  et al. Antitumor Effects and Mechanisms of AZD4547 on FGFR2-Deregulated Endometrial Cancer Cells. Mol Cancer Ther 14:2292-302 (2015). Read more (PubMed: 26294741) »
  • Doughton G  et al. Formation of a polarised primitive endoderm layer in embryoid bodies requires fgfr/erk signalling. PLoS One 9:e95434 (2014). Read more (PubMed: 24752320) »
  • Gavine PR  et al. AZD4547: an orally bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor tyrosine kinase family. Cancer Res 72:2045-56 (2012). Read more (PubMed: 22369928) »

See 0 Publications for this product

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