製品の概要

  • 製品名Anti-ATP6V0A2 antibody
    ATP6V0A2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to ATP6V0A2
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Cow
  • 免疫原

    Recombinant fragment corresponding to a region within amino acids 156-404 of Human ATP6V0A2 (NP_036595).

  • ポジティブ・コントロール
    • 293T, A431 and H1299 whole cell lysates; DLD1 xenograft; HeLa, HepG2, MOLT4 and Raji cell lysates

法規制情報

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab96803 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/3000. Predicted molecular weight: 98 kDa.
IHC-P 1/100 - 1/500.

ターゲット情報

  • 機能Part of the proton channel of V-ATPases. Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH.
  • 関連疾患Defects in ATP6V0A2 are the cause of cutis laxa autosomal recessive type 2A (ARCL2A) [MIM:219200]. An autosomal recessive disorder characterized by an excessive congenital skin wrinkling, a large fontanelle with delayed closure, a typical facial appearance with downslanting palpebral fissures, a general connective tissue weakness, and varying degrees of growth and developmental delay and neurological abnormalities. Some affected individuals develop seizures and mental deterioration later in life, whereas the skin phenotype tends to become milder with age. At the molecular level, an abnormal glycosylation of serum proteins is observed in many cases.
    Defects in ATP6V0A2 are a cause of wrinkly skin syndrome (WSS) [MIM:278250]. WSS is rare autosomal recessive disorder characterized by wrinkling of the skin of the dorsum of the hands and feet, an increased number of palmar and plantar creases, wrinkled abdominal skin, multiple musculoskeletal abnormalities, microcephaly, growth failure and developmental delay.
  • 配列類似性Belongs to the V-ATPase 116 kDa subunit family.
  • 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 細胞内局在Cell membrane. Endosome membrane. In kidney proximal tubules, also detected in subapical vesicles.
  • Information by UniProt
  • 参照データベース
  • 別名
    • a2 antibody
    • A2V ATPase antibody
    • ARCL antibody
    • ATP6a2 antibody
    • ATP6N1D antibody
    • ATP6V0A2 antibody
    • ATPase, H+ transporting, lysosomal V0 subunit a isoform 2 antibody
    • ATPase, H+ transporting, lysosomal V0 subunit a2 antibody
    • Infantile malignant osteopetrosis antibody
    • J6B7 antibody
    • Lysosomal H(+) transporting ATPase V0 subunit a2 antibody
    • Lysosomal H(+)-transporting ATPase V0 subunit a2 antibody
    • regeneration and tolerance factor antibody
    • Stv1 antibody
    • TJ6 antibody
    • TJ6M antibody
    • TJ6s antibody
    • V ATPase 116 kDa isoform a2 antibody
    • V type proton ATPase 116 kDa subunit a antibody
    • V type proton ATPase 116 kDa subunit a isoform 2 antibody
    • V-ATPase 116 kDa isoform a2 antibody
    • V-type proton ATPase 116 kDa subunit a isoform 2 antibody
    • Vacuolar proton translocating ATPase 116 kDa subunit a antibody
    • Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2 antibody
    • Vph1 antibody
    • VPP2_HUMAN antibody
    • WSS antibody
    see all

Anti-ATP6V0A2 antibody 画像

  • All lanes : Anti-ATP6V0A2 antibody (ab96803) at 1/10000 dilution

    Lane 1 : 293T whole cell lysate
    Lane 2 : A431 whole cell lysate
    Lane 3 : H1299 whole cell lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 98 kDa
  • ab96803, at 1/500 dilution, staining ATP6V0A2 in paraffin-embedded DLD1 xenograft by Immunohistochemistry.

Anti-ATP6V0A2 antibody (ab96803) 使用論文

ab96803 has not yet been referenced specifically in any publications.

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