Anti-ATP-binding cassette sub-family A member 3 抗体 (ab99856)
Key features and details
- Rabbit polyclonal to ATP-binding cassette sub-family A member 3
- Suitable for: WB, ICC/IF
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-ATP-binding cassette sub-family A member 3 antibody
ATP-binding cassette sub-family A member 3 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to ATP-binding cassette sub-family A member 3 -
由来種
Rabbit -
アプリケーション
適用あり: WB, ICC/IFmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat -
免疫原
Recombinant fragment corresponding to Human ATP-binding cassette sub-family A member 3 aa 1 to the C-terminus. BC062779.1
Database link: Q99758-2 -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.20
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab99856の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/1000 - 1/2000. Predicted molecular weight: 191 kDa.
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ICC/IF | (1) |
Use at an assay dependent concentration.
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特記事項 |
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WB
1/1000 - 1/2000. Predicted molecular weight: 191 kDa. |
ICC/IF
Use at an assay dependent concentration. |
ターゲット情報
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機能
Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol. -
組織特異性
Highly expressed in lung, followed by brain, pancreas, skeletal muscle and heart. Weakly expressed in placenta, kidney and liver. Also expressed in medullary thyroid carcinoma cells (MTC) and in C-cell carcinoma. -
関連疾患
Defects in ABCA3 are the cause of pulmonary surfactant metabolism dysfunction type 3 (SMDP3) [MIM:610921]; also called pulmonary alveolar proteinosis due to ABCA3 deficiency. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. -
配列類似性
Belongs to the ABC transporter superfamily. ABCA family.
Contains 2 ABC transporter domains. -
ドメイン
Multifunctional polypeptide with two homologous halves, each containing an hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 21 Human
- Entrez Gene: 27410 Mouse
- Entrez Gene: 302973 Rat
- Omim: 601615 Human
- SwissProt: Q99758 Human
- SwissProt: Q8R420 Mouse
- SwissProt: P16970 Rat
- Unigene: 26630 Human
see all -
別名
- ABC 3 antibody
- ABC C antibody
- ABC C transporter antibody
see all
画像
データシートおよび資料
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Datasheet download
参考文献 (2)
ab99856 は 2 報の論文で使用されています。
- Kathiriya JJ et al. Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells. Nat Cell Biol 24:10-23 (2022). PubMed: 34969962
- Sengupta A et al. A New Immortalized Human Alveolar Epithelial Cell Model to Study Lung Injury and Toxicity on a Breathing Lung-On-Chip System. Front Toxicol 4:840606 (2022). PubMed: 35832493