製品の概要

  • 製品名Anti-ATIC antibody
    ATIC 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to ATIC
  • アプリケーション適用あり: WB, ICC/IFmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Cow, Pig
  • 免疫原

    Recombinant protein fragment corresponding to a region within amino acids 310 - 550 of Human ATIC

  • ポジティブ・コントロール
    • WB: HepG2 whole cell lysates IF: HeLa cells

法規制情報

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab96638 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/3000. Predicted molecular weight: 65 kDa.
ICC/IF 1/100 - 1/200.

ターゲット情報

  • 機能Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis.
  • パスウェイPurine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.
    Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.
  • 関連疾患Defects in ATIC are the cause of AICA-ribosuria [MIM:608688]; also known as AICA-ribosiduria. AICA-ribosuria is a neurologically devastating inborn error of purine biosynthesis. AICA-ribosuria patients excrete massive amounts of AICA-riboside in the urine and accumulate AICA-ribotide and its derivatives in erythrocytes and fibroblasts. AICA-ribosuria causes profound mental retardation, epilepsy, dysmorphic features and congenital blindness.
  • 配列類似性Belongs to the purH family.
  • ドメインThe IMP cyclohydrolase activity resides in the N-terminal region.
  • Information by UniProt
  • 参照データベース
  • 別名
    • AICAR formyltransferase/IMP cyclohydrolase antibody
    • 5 aminoimidazole 4 carboxamide 1 beta D ribonucleotide transformylase/inosinicase antibody
    • 5 aminoimidazole 4 carboxamide ribonucleotide formyltransferase antibody
    • 5 aminoimidazole 4 carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase antibody
    • 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase antibody
    • AICAR antibody
    • AICAR formyltransferase/IMP cyclohydrolase bifunctional enzyme antibody
    • AICAR transformylase antibody
    • AICARFT antibody
    • AICARFT/IMPCHASE antibody
    • ATIC antibody
    • Bifunctional purine biosynthesis protein PURH antibody
    • epididymis secretory sperm binding protein Li 70p antibody
    • FLJ93545 antibody
    • HEL-S-70p antibody
    • IMP cyclohydrolase antibody
    • IMP synthase antibody
    • IMP synthetase antibody
    • IMPCHASE antibody
    • Inosinicase antibody
    • OK/SW-cl.86 antibody
    • Phosphoribosylaminoimidazolecarboxamide formyltransferase antibody
    • Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase antibody
    • PUR9_HUMAN antibody
    • PURH antibody
    see all

Anti-ATIC antibody 画像

  • Anti-ATIC antibody (ab96638) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

    Predicted band size : 65 kDa
  • ab96638, at a 1/200 dilution, staining ATIC in paraformaldehyde-fixed HeLa cells by Immunofluorescence analysis. The right image is merged with a DNA probe.

Anti-ATIC antibody (ab96638) 使用論文

ab96638 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab96638.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"