製品の概要

  • 製品名Anti-ATF7 antibody
    ATF7 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to ATF7
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Horse, Cow, Dog, Chimpanzee
  • 免疫原

    Synthetic peptide:

    C-HVIMTPQSQSAGR

    , corresponding to C terminal amino acids 471-483 of Human ATF7 (NP_006847).

  • ポジティブ・コントロール
    • HeLa cell lysate in RIPA buffer.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab77083 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 35 kDa (predicted molecular weight: 53 kDa).

ターゲット情報

  • 機能Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family.
    Isoform 4/ATF-A0 acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter.
  • 組織特異性Expressed in heart, lung and skeletal muscle. Isoform 4 is expressed in various tissues including heart, brain, placenta, lung and skeletal muscle. Highest levels in skeletal muscle. Lowest in lung and placenta.
  • 配列類似性Belongs to the bZIP family.
    Contains 1 bZIP domain.
    Contains 1 C2H2-type zinc finger.
  • 翻訳後修飾On EGF stimulation, phosphorylated first on Thr-53 allowing subsequent phosphorylation on Thr-51. This latter phosphorylation prevents sumoylation, increases binding to TAF12 and enhances transcriptional activity.
    Sumoylation delays nuclear localization and inhibits transactivation activity through preventing binding to TAF12. RANBP2 appears to be the specific E3 ligase.
  • 細胞内局在Nucleus. Nucleus > nucleoplasm. Mainly nucleoplasmic. Restricted distribution to the perinuculear region. The sumoylated form locates to the nuclear periphery.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 1110012F10Rik antibody
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    • AI549878 antibody
    • ATF7 antibody
    • Atf7 protein antibody
    • ATF7_HUMAN antibody
    • ATFA antibody
    • C130020M04Rik antibody
    • cAMP-dependent transcription factor ATF-7 antibody
    • Cyclic AMP-dependent transcription factor ATF 7 antibody
    • Cyclic AMP-dependent transcription factor ATF-7 antibody
    • MGC31554 antibody
    • MGC57182 antibody
    • Transcription factor ATF A antibody
    • Transcription factor ATF-A antibody
    see all

Anti-ATF7 antibody 画像

Anti-ATF7 antibody (ab77083) 使用論文

ab77083 has not yet been referenced specifically in any publications.

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