製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to Ataxin 7
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 360-409 (RSLTCKTHSL TQRRAVQGRR KRFDVLLAEH KNKTREKELI RHPDSQQPPQ) of Human Ataxin 7 (NP_000324).

  • ポジティブ・コントロール
    • ACHN cell lysate

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • バッファー
    Preservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab90907 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 95 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 関連性
    Ataxin 7 is a protein of unknown function. It may be the human orthologue of the yeast SAGA SGF73 subunit and a subunit of the human TFTC-like transcriptional complexes. Spinocerebellar ataxia 7 (one of a group of hereditary neurodegenrative diseases) is caused by an expanded trinucleotide repeat in the gene encoding ataxin 7. Ataxin 7 is typically located in the cytoplasm and on the nuclear membrane of normal brain neurons. In cells where there is a mutation of the SCA7 gene, ataxin 7 accumulates in intranuclear inclusions and can result in cell death.
  • 細胞内局在
    Cytoplasmic (isoform b) and Nuclear (isoform a)
  • 参照データベース
  • 別名
    • ADCAII antibody
    • ATXN 7 antibody
    • OPCA III antibody
    • OPCA3 antibody
    • SCA 7 antibody
    • SCA7 antibody
    • Spinocerebellar Ataxia 7 antibody
    • Spinocerebellar ataxia type 7 protein antibody
    see all

画像

  • Anti-Ataxin 7 antibody (ab90907) at 1 µg/ml (in 5% skim milk / PBS buffer) + ACHN cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 95 kDa

プロトコール

参考文献

This product has been referenced in:
  • Mohan RD  et al. Loss of Drosophila Ataxin-7, a SAGA subunit, reduces H2B ubiquitination and leads to neural and retinal degeneration. Genes Dev 28:259-72 (2014). Read more (PubMed: 24493646) »

See 1 Publication for this product

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