The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
追加情報WB: 1/500 - 1/1000. Detects a band of approximately 95 kDa (predicted molecular weight: Isoform 2, 98 kDa; Isoform 1, 154 kDa).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
機能Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility.
関連疾患Note=A chromosomal aberration involving ASXL2 is a cause of therapy-related myelodysplastic syndrome. Translocation t(2;8)(p23;p11.2) with MYST3 generates a MYST3-ASXL2 fusion protein.
配列類似性Belongs to the Asx family. Contains 1 PHD-type zinc finger.
ドメインContains two Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, which may be required for an association with nuclear receptors.
翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.