製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to ASS1
  • アプリケーション
    適用あり: WB, IP, ELISA, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Dog, Pig
  • 免疫原

    Synthetic peptide:

    C-ENPKNQAPPGLYTKTQD

    , corresponding to internal sequence amino acids 196-212 of Human ASS1 (P00966).

  • ポジティブ・コントロール
    • Human kidney and liver tissue; Human kidney lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab109753 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.01 - 0.03 µg/ml. Predicted molecular weight: 47 kDa.
IP Use at an assay dependent dilution.
ELISA 1/64000.
IHC-P Use a concentration of 2.5 µg/ml.

ターゲット情報

  • パスウェイ
    Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.
    Nitrogen metabolism; urea cycle; (N(omega)-L-arginino)succinate from L-aspartate and L-citrulline: step 1/1.
  • 関連疾患
    Defects in ASS1 are the cause of citrullinemia type 1 (CTLN1) [MIM:215700]. Citrullinemia belongs to the urea cycle disorders. It is an autosomal recessive disease characterized primarily by elevated serum and urine citrulline levels. Ammonia intoxication is another manifestation. CTLN1 usually manifests in the first few days of life. Affected infants appear normal at birth, but as ammonia builds up in the body they present symptoms such as lethargy, poor feeding, vomiting, seizures and loss of consciousness. Less commonly, a milder CTLN1 form can develop later in childhood or adulthood.
  • 配列類似性
    Belongs to the argininosuccinate synthase family. Type 1 subfamily.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Argininosuccinate synthase 1 antibody
    • Argininosuccinate synthase antibody
    • Argininosuccinate synthetase 1 antibody
    • ASS antibody
    • Ass-1 antibody
    • ass1 antibody
    • ASSA antibody
    • ASSY_HUMAN antibody
    • Citrulline aspartate ligase antibody
    • Citrulline--aspartate ligase antibody
    • CTLN1 antibody
    see all

画像

  • ab109753, at 2.5 µg/ml, staining ASS1 in formalin fixed, paraffin embedded Human kidney tissue by Immunohistochemistry.
  • ab109753, at 2.5 µg/ml, staining ASS1 in formalin fixed, paraffin embedded Human liver tissue by Immunohistochemistry.
  • Anti-ASS1 antibody (ab109753) at 0.03 µg/ml + Human kidney lysate (in RIPA buffer) at 35 µg

    Predicted band size : 47 kDa

参考文献

ab109753 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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