Anti-Aspergillus 抗体 (ab20419)
Key features and details
- Rabbit polyclonal to Aspergillus
- Suitable for: ELISA, IHC-Fr, IHC-P
- Reacts with: Aspergillus nidulans
- Isotype: IgG
製品の概要
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製品名
Anti-Aspergillus antibody
Aspergillus 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Aspergillus -
由来種
Rabbit -
アプリケーション
適用あり: ELISA, IHC-Fr, IHC-Pmore details -
種交差性
交差種: Aspergillus nidulans -
免疫原
Tissue, cells or virus corresponding to Aspergillus. Soluble extract from A. fumigatus, A. flavus, A. niger and A. terreus.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
Preservative: 0.1% Sodium azide
Constituent: 0.0268% PBS -
Concentration information loading...
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精製度
Protein A purified -
特記事項(精製)
>95% pure -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab20419の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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ELISA |
Use at an assay dependent concentration.
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IHC-Fr |
Use at an assay dependent concentration.
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IHC-P |
Use at an assay dependent concentration.
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特記事項 |
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ELISA
Use at an assay dependent concentration. |
IHC-Fr
Use at an assay dependent concentration. |
IHC-P
Use at an assay dependent concentration. |
ターゲット情報
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関連性
The genus Aspergillus includes over 185 species. Around 20 species have been reported as causative agents of opportunistic infections in humans. Among these, Aspergillus fumigatus is the most commonly isolated species, followed by Aspergillus flavus. Aspergillus fumigatus is the major cause of aspergillosis. This organism causes both invasive and allergic aspergillosis. Aspergillus also produce fungal toxins called mycotoxins. Aflatoxin is produced by Aspergillus flavus as it grows on corn and peanuts. The toxin is poisonous to humans by ingestion and causes liver disease. Aspergillus nidulans can produce the mycotoxin sterigmatocystin. This toxin has been shown to produce liver and kidney damage in lab animals. Aspergillus oschraceus,found in grains, soil and salted food products can produce a kidney toxin called oschratoxin A, which may produce oschratoxicosis in humans. Ochratoxin may also be produced by other aspergillus and penicillium species. Other toxins that can be produced by this fungus include penicillic acid, xanthomegnin and viomellein. Aspergillus infections have a very high mortality rate. Their incidence is growing because of the increased number of immunocompromised patients. Previous to antibodies such as these, special stains were used to identify aspergillus. Aspergillus oryzae and Aspergillus niger are used extensively in industrial scale fermentation to produce enzymes for processing household food and drink products.
画像
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ab20419, staining Aspergillus (green) in lung tissue from a murine model of corticosteroid-induced invasive pulmonary aspergillosis, by Immunohistochemistry.
Tissue was fixed in cold acetone for 15 min, followed by washing and blocking with normal serum block at RT for 30 min. Sections were incubated overnight at 4°C with primary antibody. An AlexaFluor®488-conjugated goat anti-rabbit IgG (1/00) was used as the secondary antibody. -
ab20419, staining Aspergillus (green) in lung tissue from a murine model of chemotherapy-induced invasive pulmonary aspergillosis, by Immunohistochemistry.
Tissue was fixed in cold acetone for 15 min, followed by washing and blocking with normal serum block at RT for 30 min. Sections were incubated overnight at 4°C with primary antibody. An AlexaFluor®488-conjugated goat anti-rabbit IgG (1/00) was used as the secondary antibody.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (6)
ab20419 は 6 報の論文で使用されています。
- Narunsky-Haziza L et al. Pan-cancer analyses reveal cancer-type-specific fungal ecologies and bacteriome interactions. Cell 185:3789-3806.e17 (2022). PubMed: 36179670
- Keizer EM et al. Variation of virulence of five Aspergillus fumigatus isolates in four different infection models. PLoS One 16:e0252948 (2021). PubMed: 34242260
- Schmidt S et al. The domestic pig as human-relevant large animal model to study adaptive antifungal immune responses against airborne Aspergillus fumigatus. Eur J Immunol 50:1712-1728 (2020). PubMed: 32558930
- Watanabe I et al. Invasive aspergillosis in the aortic arch with infectious Aspergillus lesions in pulmonary bullae. Med Mycol Case Rep 7:15-9 (2015). PubMed: 27330942
- Chang SC et al. Probable Blastomyces dermatitidis Infection in a Young Rat. Vet Pathol : (2012). PubMed: 22711744
- Grahl N et al. In vivo Hypoxia and a Fungal Alcohol Dehydrogenase Influence the Pathogenesis of Invasive Pulmonary Aspergillosis. PLoS Pathog 7:e1002145 (2011). IHC-Fr . PubMed: 21811407