製品の概要

  • 製品名
    Asenapine maleate
  • 製品の詳細
    Multiple receptor antagonist. Antipsychotic agent.
  • 別名
    • ASE
  • 生理活性の詳細
    Novel, multiple receptor antagonist. Displays activity at 5-HT, dopamine, adrenoceptors and histamine receptors. (pKi values are 8.60 (5-HT1A), 8.40 (5-HT1B), 10.15 (5-HT2A), 9.75 (5-HT2B), 10.46 (5-HT2C), 8.84 (5-HT5A), 9.60 (5-HT6), 9.94 (5-HT7), 8.85 (D1), 8.90 (D2L), 8.84 (D2S), 9.38 (D3), 8.95 (D4), 8.93 (α1A), 8.9 (α2A), 9.49 (α2B), 8.91 (α2C), 9.00 (H1) and 8.21(H2)). Increases dopamine, norepinephrine and acetylcholine efflux. Antipsychotic in vivo.
  • 精製度
    > 99%

製品の特性

参考文献

This product has been referenced in:
  • Shahid M  et al. Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. J Psychopharmacol 23:65-73 (2009). Read more (PubMed: 18308814) »
  • Marston HM  et al. Asenapine effects in animal models of psychosis and cognitive function. Psychopharmacology (Berl) 206:699-714 (2009). Read more (PubMed: 19462162) »
  • Huang M  et al. Asenapine increases dopamine, norepinephrine, and acetylcholine efflux in the rat medial prefrontal cortex and hippocampus. Neuropsychopharmacology 33:2934-45 (2008). Read more (PubMed: 18418367) »

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