製品の概要

  • 製品名
    AS-252424
  • 製品の詳細
    Potent and selective PI3Kγ inhibitor
  • 生理活性の詳細
    Potent, selective and ATP-competitive PI3Kγ inhibitor (IC50 values are 33 nM (PI3Kγ), 935 nM (PI3Kα) and 20 μM (PI3Kβ and PI3Kδ)). Active in vivo.
  • 精製度
    > 95%

製品の特性

参考文献

This product has been referenced in:
  • Graves BM  et al. Phosphoinositide-3-kinase/akt - dependent signaling is required for maintenance of [Ca(2+)](i), I(Ca), and Ca(2+) transients in HL-1 cardiomyocytes. J Biomed Sci 19:59 (2012). Read more (PubMed: 22715995) »
  • Pomel V  et al. Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma. J Med Chem 49:3857-71 (2006). Read more (PubMed: 16789742) »
  • Condliffe AM  et al. Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood 106:1432-40 (2005). Read more (PubMed: 15878979) »

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