製品の概要

  • 製品名
    AS-041164
  • 製品の詳細
    Potent and selective PI3Kγ inhibitor
  • 生理活性の詳細
    Potent PI3K inhibitor with selectivity for PI3Kγ (IC50 = 70 nM), compared to PI3Kα, β and δ (IC50 values are 240 nM, 1.45 and 1.70 μM, respectively). Shows little or no activity against 38 other common kinases. Blocks neutrophil migration. Active in vivo.
  • 精製度
    > 98%

製品の特性

参考文献

This product has been referenced in:
  • Ferrandi C  et al. Phosphoinositide 3-kinase gamma inhibition plays a crucial role in early steps of inflammation by blocking neutrophil recruitment. J Pharmacol Exp Ther 322:923-30 (2007). Read more (PubMed: 17526805) »

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