This fast track antibody is not yet fully characterized. It is subject to these terms and conditions

製品の概要

  • 製品名Anti-ARL6 antibody
    ARL6 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to ARL6

    This product is a fast track antibody. It has been affinity purified and shows high titre values against the immunizing peptide by ELISA. Read the terms of use »

  • 特異性Reported variants (NP_816931.1, NP_115522.1) represent identical protein.
  • 種交差性

    交差が予測される動物種: Mouse, Rat, Cow, Dog, Zebrafish
  • 免疫原

    Synthetic peptide:

    KPSNAQSQDIVPT

    with a Cysteine residue linker, corresponding to internal sequence amino acids 38-50 of Mouse ARL6 (NP_062639.3).

  • 特記事項


    Reported variants (NP_816931.1, NP_115522.1) represent identical protein.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • バッファーpH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 99% Tris buffered saline, 0.5% BSA
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)ab120000 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • 一次抗体 備考Reported variants (NP_816931.1, NP_115522.1) represent identical protein.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Fast track antibodies constitute a diverse group of products that have been released to accelerate your research, but are not yet fully characterized. They have all been affinity purified and show high titre values against the immunizing peptide (by ELISA). Fast track terms of use

アプリケーション Abreviews 特記事項
WB Use at an assay dependent concentration. Predicted molecular weight: 21 kDa. Preliminary experiments gave an approx 33kDa band in Mouse Brain lysates after 1µg/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 21.0kDa according to NP_062639.3. The 33kDa band was successfully blocked by incubation with the immunizing peptide.

ターゲット情報

  • 機能Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia. May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade. Isoform 2 may be required for proper retinal function and organization.
  • 関連疾患Defects in ARL6 are a cause of Bardet-Biedl syndrome type 3 (BBS3) [MIM:209900]. Bardet-Biedl syndrome (BBS) is a genetically heterogeneous disorder characterized by usually severe pigmentary retinopathy, early onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease.
    Defects in ARL6 are the cause of retinitis pigmentosa type 55 (RP55) [MIM:613575]. RP55 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
  • 配列類似性Belongs to the small GTPase superfamily. Arf family.
  • 細胞内局在Cell projection > cilium membrane. Cytoplasm > cytoskeleton > cilium axoneme. Cytoplasm > cytoskeleton > cilium basal body. Appears in a pattern of punctae flanking the microtubule axoneme that likely correspond to small membrane-associated patches. Localizes to the so-called ciliary gate where vesicles carrying ciliary cargo fuse with the membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ADP ribosylation factor like 6 antibody
    • ADP ribosylation factor like protein 6 antibody
    • ADP-ribosylation factor-like protein 6 antibody
    • Arl6 antibody
    • ARL6_HUMAN antibody
    • Bardet Biedl syndrome 3 protein antibody
    • Bardet-Biedl syndrome 3 protein antibody
    • BBS3 antibody
    • MGC32934 antibody
    see all

Anti-ARL6 antibody (ab120000) 使用論文

ab120000 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"