製品の概要

  • 製品名Anti-ARIH2 antibody
    ARIH2 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to ARIH2
  • アプリケーション適用あり: WB, ICC/IF, IPmore details
  • 種交差性
    交差種: Mouse, Human
    交差が予測される動物種: Rat, Cow, Dog, Xenopus laevis, Zebrafish
  • 免疫原

    Synthetic peptide:

    EQRRRTLLKDFHDT

    , corresponding to C terminal amino acids 480-493 of Human ARIH2.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab17014 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 3 µg/ml.

Approx 60kDa band observed in nuclear lysates of Hela and K562 (Calculated MW of 57.8kDa according to NP_006312.1). Customer's experiments gave a band at approx 60kDa in lysates in both Human HeLa and Mouse Muscle (IM2 & C2C12) cells. This band disappeared after RNAi knock-down.

ICC/IF Use at an assay dependent concentration.
IP Use at an assay dependent concentration.

ターゲット情報

  • 機能E3 ubiquitin-protein ligase mediating 'Lys-48'-and 'Lys-63'-linked polyubiquitination and subsequent proteasomal degradation of modified proteins. May play a role in myelopoiesis.
  • 組織特異性Widely expressed with higher expression in granulocytes.
  • パスウェイProtein modification; protein ubiquitination.
  • 配列類似性Belongs to the RBR family. Ariadne subfamily.
    Contains 1 IBR-type zinc finger.
    Contains 2 RING-type zinc fingers.
  • ドメインRING-type 1 and RING-type 2 are required for the inhibitory function in myelopoiesis.
  • 翻訳後修飾Ubiquitinated. Ubiquitination promotes proteasomal degradation.
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 細胞内局在Nucleus. Cytoplasm.
  • Information by UniProt
  • 参照データベース
  • 別名
    • HT005 antibody
    • all trans retinoic acid inducible RING finger antibody
    • Ari 2 antibody
    • Ari-2 antibody
    • ARI2 antibody
    • ARI2_HUMAN antibody
    • Ariadne 2 antibody
    • Ariadne 2 protein homolog antibody
    • ariadne homolog 2 (Drosophila) antibody
    • ariadne homolog 2 antibody
    • Ariadne RBR E3 ubiquitin protein ligase 2 antibody
    • ARIH 2 antibody
    • Arih2 antibody
    • E3 ubiquitin protein ligase ARIH2 antibody
    • E3 ubiquitin-protein ligase ARIH2 antibody
    • protein ariadne 2 homolog antibody
    • Protein ariadne-2 homolog antibody
    • Triad 1 antibody
    • TRIAD1 antibody
    • Triad1 protein antibody
    • UIP48 antibody
    see all

Anti-ARIH2 antibody 画像

  • All lanes : Anti-ARIH2 antibody (ab17014) at 2 µg/ml

    Lane 1 : HeLa nuclear lysate
    Lane 2 : K562 nuclear lysate

    Lysates/proteins at 35 µg per lane.

Anti-ARIH2 antibody (ab17014) 使用論文

ab17014 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab17014.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"