製品の概要

  • 製品名Anti-ARID5B antibody
    ARID5B 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to ARID5B
  • アプリケーション適用あり: ELISA, Sandwich ELISAmore details
  • 種交差性
    交差種: Recombinant Fragment
    交差が予測される動物種: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 1483-1583 of Human ARID5B with a proprietary tag (XP_084482.3).

  • ポジティブ・コントロール
    • Recombinant Human ARID5B Protein.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab118112 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA Use at an assay dependent dilution.
Sandwich ELISA Use a concentration of 10 µg/ml.

ターゲット情報

  • 機能Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer.
  • 組織特異性Widely expressed, including in liver (at protein level).
  • 関連疾患Note=Defects in ARID5B ay be a cause of susceptibility to coronary atherosclerosis in the Japanese population.
    Defects in ARID5B may be a cause of susceptibility to acute lymphoblastic leukemia (ALL) [MIM:613065]. Note=ALL is a subtype of acute leukemia, a cancer of the white blood cells. ALL is a malignant disease of bone marrow and the most common malignancy diagnosed in children. The malignant cells are lymphoid precursor cells (lymphoblasts) that are arrested in an early stage of development. The lymphoblasts replace the normal marrow elements, resulting in a marked decrease in the production of normal blood cells. Consequently, anemia, thrombocytopenia, and neutropenia occur to varying degrees. The lymphoblasts also proliferate in organs other than the marrow, particularly the liver, spleen, and lymphonodes.
  • 配列類似性Belongs to the ARID5B family.
    Contains 1 ARID domain.
  • ドメインThe ARID domain mediates the interaction with DNA.
  • 翻訳後修飾Methylation at Lys-336 prevents DNA-binding. Demethylation by PHF2 promotes recruitment of the PHF2-ARID5B complex to promoters.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ARI5B_HUMAN antibody
    • ARID domain-containing protein 5B antibody
    • Arid5b antibody
    • AT rich interactive domain 5B (MRF1 like) antibody
    • AT-rich interactive domain-containing protein 5B antibody
    • DESRT antibody
    • FLJ21150 antibody
    • FLJ41888 antibody
    • Modulator recognition factor 2 (MRF2) antibody
    • Modulator recognition factor 2 antibody
    • MRF-2 antibody
    • Mrf1-like antibody
    • MRF1-like protein antibody
    • MRF2 antibody
    • OTTHUMP00000019668 antibody
    • RP11 341A19.1 antibody
    see all

Anti-ARID5B antibody 画像

  • ab118112 at 10 µg/ml as a capture antibody. The detection limit for recombinant tagged ARID5B is 0.3 ng/ml.

Anti-ARID5B antibody (ab118112) 使用論文

ab118112 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"