The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/50 - 1/100. Predicted molecular weight: 58 kDa.
Use a concentration of 10 µg/ml.
機能Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters.
組織特異性Detected in brain. Detected at low levels in heart.
関連疾患Defects in ARHGEF9 are a cause of startle disease with epilepsy (STHEE) [MIM:300607]; also known as hyperekplexia with epilepsy. Startle disease is a genetically heterogeneous neurologic disorder. STHE is characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile stimuli.