製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to ARHGEF11
  • 由来種
    Rabbit
  • 特異性
    This antibody detects endogenous levels of total ARHGEF11 protein.
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic peptide derived from the N terminal region of Human ARHGEF11.

  • ポジティブ・コントロール
    • A549 and COLO cell extracts.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab110059 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Predicted molecular weight: 168 kDa.

ターゲット情報

  • 機能
    May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.
  • 組織特異性
    Ubiquitously expressed.
  • 配列類似性
    Contains 1 DH (DBL-homology) domain.
    Contains 1 PDZ (DHR) domain.
    Contains 1 PH domain.
    Contains 1 RGSL (RGS-like) domain.
  • ドメイン
    The poly-Pro region is essential for plasma membrane localization upon stimulation.
  • 細胞内局在
    Cytoplasm. Membrane. Translocated to the membrane upon stimulation.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ARHGB_HUMAN antibody
    • ARHGEF 11 antibody
    • ARHGEF11 antibody
    • DKFZp667F1223 antibody
    • Glutamate transporter EAAT4 associated protein 48 antibody
    • GTRAP 48 antibody
    • GTRAP48 antibody
    • KIAA0380 antibody
    • OTTHUMP00000038716 antibody
    • OTTHUMP00000038717 antibody
    • PDZ RHOGEF antibody
    • PDZ-RhoGEF antibody
    • Rho guanine exchange factor (GEF) 11 antibody
    • Rho guanine nucleotide exchange factor (GEF) 11 antibody
    • Rho guanine nucleotide exchange factor 11 antibody
    • RhoA specific guanine nucleotide exchange factor antibody
    • RhoGEF glutamate transport modulator antibody
    see all

画像

  • All lanes : Anti-ARHGEF11 antibody (ab110059) at 1/500 dilution

    Lane 1 : A549 cell extract
    Lane 2 : COLO cell extract
    Lane 3 : COLO cell extract with immunizing peptide

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 168 kDa

プロトコール

参考文献

This product has been referenced in:
  • Zhang W  et al. ARHGEF11 affecting the placental insulin signaling pathway in fetal macrosomia of normal glucose tolerance pregnant women. Placenta 63:7-14 (2018). WB, IHC-P . Read more (PubMed: 29486856) »

See 1 Publication for this product

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