製品の概要

  • 製品名Anti-ARHGEF1 antibody
    ARHGEF1 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to ARHGEF1
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment: CRPGPEGQLA ATALRKVLSL KQLLFPAEED NGAGPPRDGD GVPGGGPLSP ARTQEIQENL LSLEETMKQL EELEEEFCRL RPLLSQLGGN SVPQPGCT, corresponding to amino acids 830-927 of Human ARHGEF1

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • 精製度Protein G purified
  • ポリ/モノモノクローナル
  • アイソタイプIgG2a
  • 軽鎖の種類kappa
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab56464 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報WB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.
    • 組織特異性Ubiquitously expressed.
    • 配列類似性Contains 1 DH (DBL-homology) domain.
      Contains 1 PH domain.
      Contains 1 RGSL (RGS-like) domain.
    • ドメインThe RGSL domain, also known as rgRGS domain, is necessary but not sufficient for GAP activity.
      The DH domain is involved in interaction with CCPG1.
    • 翻訳後修飾Phosphorylated by PKCA. Angiotensin-2 induced Tyr-738 phosphorylation is mediated by JAK2.
    • 細胞内局在Cytoplasm. Membrane. Translocated to the membrane by activated GNA13 or LPA stimulation.
    • Information by UniProt
    • 参照データベース
    • 別名
      • 115 kD protein antibody
      • 115 kDa guanine nucleotide exchange factor antibody
      • ARHG1_HUMAN antibody
      • ARHGEF 1 antibody
      • ARHGEF1 antibody
      • GEF 1 antibody
      • GEF1 antibody
      • LBCL 2 antibody
      • LBCL2 antibody
      • LSC antibody
      • Lsc homolog antibody
      • p115 RhoGEF antibody
      • p115-RhoGEF antibody
      • p115RhoGEF antibody
      • Rho guanine nucleotide exchange factor (GEF) 1 antibody
      • Rho guanine nucleotide exchange factor 1 antibody
      • Sub1.5 antibody
      see all

    Anti-ARHGEF1 antibody 画像



    • Predicted band size : 102 kDa
      ARHGEF1 antibody (ab56464) at 1ug/lane + K-562 cell lysate at 25ug/lane.

    Anti-ARHGEF1 antibody (ab56464) 使用論文

    ab56464 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab56464.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"