製品の概要

  • 製品名Anti-ARHGEF1 antibody
    ARHGEF1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to ARHGEF1
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 163-192 of Human ARHGEF1 (NP_945328.1, NP_945353.1, NP_004697.2).

  • ポジティブ・コントロール
    • CEM cell line lysate.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • バッファーPreservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)ab123582 is purified through a protein A column, followed by peptide affinity purification.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab123582 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 102 kDa.

ターゲット情報

  • 機能Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.
  • 組織特異性Ubiquitously expressed.
  • 配列類似性Contains 1 DH (DBL-homology) domain.
    Contains 1 PH domain.
    Contains 1 RGSL (RGS-like) domain.
  • ドメインThe RGSL domain, also known as rgRGS domain, is necessary but not sufficient for GAP activity.
    The DH domain is involved in interaction with CCPG1.
  • 翻訳後修飾Phosphorylated by PKCA. Angiotensin-2 induced Tyr-738 phosphorylation is mediated by JAK2.
  • 細胞内局在Cytoplasm. Membrane. Translocated to the membrane by activated GNA13 or LPA stimulation.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 115 kD protein antibody
    • 115 kDa guanine nucleotide exchange factor antibody
    • ARHG1_HUMAN antibody
    • ARHGEF 1 antibody
    • ARHGEF1 antibody
    • GEF 1 antibody
    • GEF1 antibody
    • LBCL 2 antibody
    • LBCL2 antibody
    • LSC antibody
    • Lsc homolog antibody
    • p115 RhoGEF antibody
    • p115-RhoGEF antibody
    • p115RhoGEF antibody
    • Rho guanine nucleotide exchange factor (GEF) 1 antibody
    • Rho guanine nucleotide exchange factor 1 antibody
    • Sub1.5 antibody
    see all

Anti-ARHGEF1 antibody 画像

  • Anti-ARHGEF1 antibody (ab123582) at 1/100 dilution + CEM cell line lysate at 35 µg

    Predicted band size : 102 kDa

Anti-ARHGEF1 antibody (ab123582) 使用論文

ab123582 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab123582.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"