製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to ARHGAP21
  • アプリケーション
    適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    antigen sequence: VPPCLTTSAP LIRRQLSHDH ESVGPPSLDA QPNSKTERSK SYDEGLDDYR EDAKLSFKHV SSLKGIKIAD SQKSSEDSGS RKDSSSEVFS DAAKEG, corresponding to amino acids 840-935 of Human ARHGAP21.

  • ポジティブ・コントロール
    • Human gall bladder tissue.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab122350 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能
    Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions.
  • 組織特異性
    Widely expressed with higher expression in brain, heart, skeletal muscle and placenta.
  • 配列類似性
    Contains 1 PDZ (DHR) domain.
    Contains 1 PH domain.
    Contains 1 Rho-GAP domain.
  • 細胞内局在
    Golgi apparatus membrane. Cell junction. Cytoplasmic vesicle membrane. Cytoplasm > cytoskeleton. Localization to the Golgi is dependent on interaction with GTP-bound ARF1.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Arhgap21 antibody
    • KIAA1424 antibody
    • RHG21_HUMAN antibody
    • Rho GTPase-activating protein 10 antibody
    • Rho GTPase-activating protein 21 antibody
    • Rho-type GTPase-activating protein 21 antibody
    see all

画像

  • ab122350, at 1/200 dilution, staining ARHGAP21 in paraffin-embedded Human gall bladder tissue by Immunohistochemistry.

プロトコール

参考文献

ab122350 has not yet been referenced specifically in any publications.

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