Anti-Aquaporin 2 (phospho S261) 抗体 (ab64154)

製品の概要

• 製品名Anti-Aquaporin 2 (phospho S261) antibody
  Aquaporin 2 一次抗体 製品一覧
• 製品の詳細
  Rabbit polyclonal to Aquaporin 2 (phospho S261)
• 特異性This antibody is specific for ~29k Aquaporin 2 protein phosphorylated at Ser261. It also recognizes the glycosylated form of Aquaporin 2 at ~ 37k. Immunolabeling of the Aquaporin 2 band is blocked by preadsorption with the phospho peptide used as antigen but not by the corresponding dephospho peptide.
• アプリケーション適用あり: WB, Flow Cytmore details
• 種交差性
  交差種: Rat
  交差が予測される動物種: Mouse, Chicken, Cow, Dog, Human, Non human primates
• 免疫原

  Phosphopeptide corresponding to amino acid residues surrounding the phospho Serine 261 of rat Aquaporin 2.

• ポジティブ･コントロール
  • Rat kidney lysate.

製品の特性

• 製品の状態Liquid
• 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• バッファーPreservative: None
  Constituents: 50% Glycerol, 0.1mg/ml BSA, 150mM Sodium chloride, 10mM HEPES, pH 7.5
• Concentration information loading...
• 精製度Immunogen affinity purified
• ポリ/モノポリクローナル
• アイソタイプIgG
• 研究分野
  • Signal Transduction
  • Metabolism
  • Plasma Membrane
  • Channels

  • Metabolism
  • Types of disease
  • Cancer

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

アプリケーション

ターゲット情報

• 機能Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
• 組織特異性Expressed in renal collecting tubules.
• 関連疾患Diabetes insipidus, nephrogenic, autosomal
• 配列類似性Belongs to the MIP/aquaporin (TC 1.A.8) family.
• ドメインAquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
• 翻訳後修飾Ser-256 phosphorylation is necessary and sufficient for expression at the apical membrane. Endocytosis is not phosphorylation-dependent.
• 細胞内局在Apical cell membrane. Basolateral cell membrane. Cytoplasmic vesicle membrane. Golgi apparatus, trans-Golgi network membrane. Shuttles from vesicles to the apical membrane. Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane. PLEKHA8/FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated.

• Target information above from: UniProt accession P41181 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 539870 Cow
  • Entrez Gene: 359 Human
  • Entrez Gene: 11827 Mouse
  • Entrez Gene: 25386 Rat
  • Omim: 107777 Human
  • SwissProt: P79099 Cow
  • SwissProt: P79144 Dog
  • SwissProt: P41181 Human

  • SwissProt: P56402 Mouse
  • SwissProt: P34080 Rat
  • Unigene: 130730 Human
  • Unigene: 20206 Mouse
  • Unigene: 90076 Rat

  see all
• 別名
  • ADH water channel antibody
  • AQP 2 antibody
  • AQP CD antibody

  • AQP-2 antibody
  • AQP-CD antibody
  • AQP2 antibody
  • AQP2_HUMAN antibody
  • AQPCD antibody
  • Aquaporin 2 collecting duct antibody
  • Aquaporin CD antibody
  • Aquaporin-2 antibody
  • Aquaporin-CD antibody
  • Aquaporin2 antibody
  • Aquaporine 2 antibody
  • Collecting duct water channel protein antibody
  • MGC34501 antibody
  • Water channel aquaporin 2 antibody
  • Water channel protein for renal collecting duct antibody
  • WCH CD antibody
  • WCH-CD antibody
  • WCHCD antibody

  see all