製品の概要

  • 製品名Anti-Aquaporin 2 antibody
    Aquaporin 2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Aquaporin 2
  • アプリケーション適用あり: IHC-P, ICC/IF, WB, ELISAmore details
  • 種交差性
    交差種: Mouse, Rat
    交差が予測される動物種: Human, Pig
  • 免疫原

    A 15 aa synthetic MAP peptide (Rat) (C terminal). This peptide is predicted to be cytoplasmic.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab15116 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use at an assay dependent concentration. PubMed: 21576461
ICC/IF 1/500.
WB 1/1000 - 1/5000. Predicted molecular weight: 29 kDa.
ELISA 1/10000 - 1/50000.

ターゲット情報

  • 機能Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
  • 組織特異性Expressed in renal collecting tubules.
  • 関連疾患Diabetes insipidus, nephrogenic, autosomal
  • 配列類似性Belongs to the MIP/aquaporin (TC 1.A.8) family.
  • ドメインAquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
  • 翻訳後修飾Ser-256 phosphorylation is necessary and sufficient for expression at the apical membrane. Endocytosis is not phosphorylation-dependent.
  • 細胞内局在Apical cell membrane. Basolateral cell membrane. Cytoplasmic vesicle membrane. Golgi apparatus, trans-Golgi network membrane. Shuttles from vesicles to the apical membrane. Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane. PLEKHA8/FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ADH water channel antibody
    • AQP 2 antibody
    • AQP CD antibody
    • AQP-2 antibody
    • AQP-CD antibody
    • AQP2 antibody
    • AQP2_HUMAN antibody
    • AQPCD antibody
    • Aquaporin 2 collecting duct antibody
    • Aquaporin CD antibody
    • Aquaporin-2 antibody
    • Aquaporin-CD antibody
    • Aquaporin2 antibody
    • Aquaporine 2 antibody
    • Collecting duct water channel protein antibody
    • MGC34501 antibody
    • Water channel aquaporin 2 antibody
    • Water channel protein for renal collecting duct antibody
    • WCH CD antibody
    • WCH-CD antibody
    • WCHCD antibody
    see all

Anti-Aquaporin 2 antibody (ab15116) 使用論文

This product has been referenced in:

See all 5 Publications for this product

Product Wall

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Immunocytochemistry/ Immunofluorescence
Blocking step Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 1µg/mL · Temperature: 25°C
Sample Mouse Cell (mouse kidney TISSUE)
Specification mouse kidney TISSUE
Permeabilization Yes - triton-X
Fixative Acetone
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投稿 Aug 08 2013

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