製品の概要

  • 製品名Anti-APPBP1 antibody - N-terminal
    APPBP1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to APPBP1 - N-terminal
  • アプリケーション適用あり: ELISA, WB, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide from the N-terminal region of human APPBP1 conjugated to KLH.

  • ポジティブ・コントロール
    • APPBP1-transfected 293 cells lysate; human brain tissue.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab71542 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/1000.
WB 1/50 - 1/100. Predicted molecular weight: 60 kDa.
IHC-P 1/10 - 1/50.

ターゲット情報

  • 機能Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.
  • 組織特異性Ubiquitous in fetal tissues. Expressed throughout the adult brain.
  • パスウェイProtein modification; protein neddylation.
  • 配列類似性Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
  • 細胞内局在Cell membrane. Colocalizes with APP in lipid rafts.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 59 kDa antibody
    • A 116A10.1 antibody
    • Amyloid beta precursor protein binding protein 1 59kD antibody
    • Amyloid beta precursor protein binding protein 1 59kDa antibody
    • Amyloid beta precursor protein binding protein 1 antibody
    • Amyloid beta precursor protein binding protein 1, 59 kDa antibody
    • Amyloid beta precursor protein-binding protein 1 antibody
    • Amyloid protein binding protein 1 antibody
    • Amyloid protein-binding protein 1 antibody
    • APP BP1 antibody
    • APP-BP1 antibody
    • APPBP 1 antibody
    • APPBP1 antibody
    • HPP 1 antibody
    • HPP1 antibody
    • NAE 1 antibody
    • NAE1 antibody
    • NEDD8 activating enzyme E1 regulatory subunit antibody
    • NEDD8 activating enzyme E1 subunit 1 antibody
    • NEDD8 activating enzyme E1 subunit antibody
    • NEDD8-activating enzyme E1 regulatory subunit antibody
    • Proto oncogene protein 1 antibody
    • Proto-oncogene protein 1 antibody
    • Protooncogene protein 1 antibody
    • ula 1 antibody
    • ULA1_HUMAN antibody
    see all

Anti-APPBP1 antibody - N-terminal 画像

  • All lanes : Anti-APPBP1 antibody - N-terminal (ab71542) at 1/50 dilution

    Lane 1 : Non-transfected 293 cell lysate
    Lane 2 : 293 cell lysate transiently transfected with the APPBP1 gene

    Lysates/proteins at 2 µg per lane.


    Predicted band size : 60 kDa
    Observed band size : 70 kDa (why is the actual band size different from the predicted?)
  • Analysis of APPBP1 expression in formalin-fixed, paraffin embedded human brain tissue using ab71542, at 1/10 dilution (peroxidase-conjugated secondary antibody; DAB staining).

Anti-APPBP1 antibody - N-terminal (ab71542) 使用論文

ab71542 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab71542.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"