Anti-Apolipoprotein A V 抗体 - N-terminal (ab71265)

製品の概要

  • 製品名Anti-Apolipoprotein A V antibody - N-terminal
    Apolipoprotein A V 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Apolipoprotein A V - N-terminal
  • アプリケーション適用あり: ELISA, WB, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide from the N-terminal region of human Apolipoprotein A V conjugated to KLH

  • ポジティブ・コントロール
    • HL60 cell line lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab71265 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/1000.
WB 1/50 - 1/100. Detects a band of approximately 41 kDa (predicted molecular weight: 41 kDa).
IHC-P 1/10 - 1/50.

ターゲット情報

  • 機能Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages.
  • 組織特異性Liver and plasma.
  • 関連疾患Defects in APOA5 are a cause of susceptibility to familial hypertriglyceridemia (FHTR)[MIM:145750].mFamilial hypertriglyceridemia is a common inherited disorder in which the concentration of very low density lipoprotein (VLDL) is elevated in the plasma. This leads to increased risk of heart disease, obesity, and pancreatitis.
    Defects in APOA5 are a cause of hyperlipoproteinemia type 5 (HLPP5) [MIM:144650]. HLPP5 is characterized by increased amounts of chylomicrons and very low density lipoprotein (VLDL) and decreased low density lipoprotein (LDL) and high density lipoprotein (HDL) in the plasma after a fast. Numerous conditions cause this phenotype, including insulin-dependent diabetes mellitus, contraceptive steroids, alcohol abuse, and glycogen storage disease type 1A (GSD1A) [MIM:232200].
  • 配列類似性Belongs to the apolipoprotein A1/A4/E family.
  • 翻訳後修飾Phosphorylation sites are present in the extracelllular medium.
  • 細胞内局在Secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Apo-AV antibody
    • ApoA-V antibody
    • Apoa5 antibody
    • APOA5_HUMAN antibody
    • ApoAV antibody
    • Apolipoprotein A-V antibody
    • Apolipoprotein A5 antibody
    • RAP3 antibody
    • Regeneration associated protein 3 antibody
    • Regeneration-associated protein 3 antibody
    see all

Anti-Apolipoprotein A V antibody - N-terminal 画像

  • Anti-Apolipoprotein A V antibody - N-terminal (ab71265) at 1/60 dilution + HL60 cell line lysate at 35 µg

    Predicted band size : 41 kDa
    Observed band size : 41 kDa
    Additional bands at : 110 kDa,28 kDa,52 kDa,65 kDa,80 kDa. We are unsure as to the identity of these extra bands.
  • ab71265 at 1/50 dilution staining Apolipoprotein - A - V N - terminal in human hepatocarcinoma tissue section by Immunohistochemistry (Formalin/ PFA fixed paraffin-embedded sections). A peroxidase conjugated secondary antibody was used followed by DAB staining.

Anti-Apolipoprotein A V antibody - N-terminal (ab71265) 使用論文

ab71265 has not yet been referenced specifically in any publications.

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