製品の概要

  • 製品名Anti-APOB48R antibody
    APOB48R 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to APOB48R
  • アプリケーション適用あり: WB, IHC-P, RIDmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    Mouse very low density lipoprotein.

  • ポジティブ・コントロール
    • Human Liver tissue.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab125128 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use at an assay dependent concentration. Predicted molecular weight: 516 kDa.
IHC-P 1/100.
RID Use at an assay dependent concentration.

ターゲット情報

  • 機能Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG-VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages.
  • 組織特異性Expressed in peripheral blood leukocytes > bone marrow = spleen > lymph node, and only faintly visible in appendix and thymus. Expressed in the brain, heart, kidney, liver, lung, pancreas, and placenta. Expressed primarily by reticuloendothelial cells: monocytes, macrophages, and endothelial cells. Expressed in atherosclerotic lesion foam cells.
  • 翻訳後修飾There are 2 forms in macrophages, the membrane-binding proteins 200 kDa (MBP 200) and 235 kDa (MBP 235), that can be reduced into a single active ligand-binding species with intermediate mobility (MBP 200R).
  • 細胞内局在Cell membrane. Binds monocyte-macrophage membrane. Thought to be anchored in the membrane through an interaction with an integral membrane protein.
  • Information by UniProt
  • 参照データベース
  • 別名
    • apo b-100 antibody
    • APOB antibody
    • apoB-48R antibody
    • APOBR antibody
    • APOBR_HUMAN antibody
    • Apolipoprotein B receptor antibody
    • Apolipoprotein B-100 receptor antibody
    • Apolipoprotein B-48 receptor antibody
    • Apolipoprotein B48 receptor antibody
    see all

Anti-APOB48R antibody 画像

  • ab125128 at 1/100 dilution staining APOB48R in formalin-fixed, paraffin-embedded Human liver tissue by Immunohistochemistry.

Anti-APOB48R antibody (ab125128) 使用論文

ab125128 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"