Apigenin, Anticancer agent (ab120141)
Key features and details
- Anticancer agent
- CAS Number: 520-36-5
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Apigenin, Anticancer agent -
製品の詳細
Anticancer agent -
生理活性の詳細
Plant flavone. Antioxidant, anti-inflammatory and anticancer properties. Effects a wide range of molecular targets including caspases, fatty acid synthase, topoisomerase and nuclear factor-κB.
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精製度
> 98% -
CAS 番号
520-36-5 -
構造式
製品の特性
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体系名
5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one -
分子量
270.24 -
分子式
C15H10O5 -
PubChem 登録番号
5280443 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
Oc1ccc(cc1)C3=CC(=O)c2c(cc(O)cc2O)O3 -
由来
Synthetic
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研究分野
画像
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2D chemical structure image of ab120141, Apigenin, Anticancer agent
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(A-D). The release of cytokines as assessed using Human Cytokine Array C1000 membranes from MDA-MB-231 cells ± TNFα ± Apigenin. [A] Ctrls, [B] TNFα-treated (40ng/mL) [C] Apigenin (40μM) and [D] TNFα-treated (40ng/mL) + Apigenin (40μM) co-treated cells.
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (1)
ab120141 は 1 報の論文で使用されています。
- Bauer D et al. Apigenin inhibits TNFa/IL-1a-induced CCL2 release through IKBK-epsilon signaling in MDA-MB-231 human breast cancer cells. PLoS One 12:e0175558 (2017). PubMed: 28441391