製品の概要

  • 製品名Anti-APH1a antibody - N-terminal
    APH1a 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to APH1a - N-terminal
  • アプリケーション適用あり: ELISA, WB, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide (10-30 aa in length) at the N-terminal of the first 110 amino acids of human APH1a, conjugated to KLH

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab60119 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/1000.
WB 1/100 - 1/500. Detects a band of approximately 27 kDa (predicted molecular weight: 29 kDa).
IHC-P 1/50 - 1/100.

ターゲット情報

  • 機能Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.
  • 組織特異性Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain. Isoform 1 and isoform 2 are nearly expressed at the same level.
  • 配列類似性Belongs to the APH-1 family.
  • 細胞内局在Endoplasmic reticulum membrane. Golgi apparatus > Golgi stack membrane. Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 6530402N02Rik antibody
    • AL138795.3 antibody
    • Anterior Pharynx Defective 1 antibody
    • Anterior pharynx defective 1 homolog A antibody
    • APH 1A antibody
    • Aph 1alpha antibody
    • APH-1a antibody
    • Aph-1alpha antibody
    • Aph1a antibody
    • APH1A gamma secretase subunit antibody
    • APH1A_HUMAN antibody
    • CGI 78 antibody
    • CGI78 antibody
    • Gamma secretase subunit APH 1A antibody
    • Gamma Secretase Subunit APH1a antibody
    • Gamma-secretase subunit APH-1A antibody
    • Likely ortholog of C. elegans anterior pharynx defective 1A antibody
    • Presenilin Stabilization Factor antibody
    • Presenilin-stabilization factor antibody
    • PSF antibody
    • UNQ579/PRO1141 antibody
    see all

Anti-APH1a antibody - N-terminal 画像

  • Anti-APH1a antibody - N-terminal (ab60119) at 1/100 dilution

    Predicted band size : 29 kDa
    Observed band size : 27 kDa (why is the actual band size different from the predicted?)
  • ab60119 at 1/100 dilution staining APH1a in human Hepatocarcinoma tissue section by Immunohistochemistry (Formalin/ PFA fixed paraffin-embedded sections). A peroxidase conjugated secondary antibody was used followed by DAB staining.

Anti-APH1a antibody - N-terminal (ab60119) 使用論文

ab60119 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab60119.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"